Triterpenoid Saponins From the Roots of Gypsophila Trichotoma Wender

Abstract : Eleven triterpenoid saponins were isolated from the roots of Gypsophila trichotoma Wender. (G. trichotoma Wender. var. trichotoma) (Caryophyllaceae), together with one known compound. The structures were established on the basis of extensive NMR analysis ((1)H, (13)C NMR, COSY, TOCSY, ROESY, HSQC, and HMBC), completed by analysis of HR-ESI-MS and ESI-MS(n). The saponins have the commonly found gypsogenin as the aglycone substituted at C-3 with trisaccharide and at C-28 with oligosaccharide through a fucose residue, as saponins isolated from Gypsophila perfoliata L. originated from China. The oligosaccharide attached to C-28 is substituted with acetyl and (or) sulfate groups. Тhe cytotoxicity of the saponin extract from G. trichotoma was evaluated against a rat alveolar macrophage-like cell line NR8383 and human leukemia cell lines U937 and BV-173. The synergistic effect of the aminoacyl saponins, previously isolated from G. trichotoma, was tested for its ability to enhance the cytotoxicity of the targeted toxin in HER14 cells.
Type de document :
Article dans une revue
Phytochemistry, Elsevier, 2013, pp.114-127. 〈10.1016/j.phytochem.2013.03.001 〉
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https://hal.univ-lorraine.fr/hal-01524710
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Soumis le : jeudi 18 mai 2017 - 16:51:54
Dernière modification le : jeudi 30 août 2018 - 11:28:01

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Laurence Voutquenne-Nazabadioko, Reneta Gevrenova, Nicolas Bories, Dominique Harakat, Charlotte Sayagh, et al.. Triterpenoid Saponins From the Roots of Gypsophila Trichotoma Wender . Phytochemistry, Elsevier, 2013, pp.114-127. 〈10.1016/j.phytochem.2013.03.001 〉. 〈hal-01524710〉

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