The white-rot fungus Hexagonia apiaria isolated in wood parks in Gabon showed a high capacity to degrade synthetic dyes used in the textile industry. The results of this study show that this fungus has an optimum growth temperature between 30°C and 40°C. Optimum physicochemical parameters of discoloration on solid culture media are 35°C and 0.3g/L. On solid culture medium, the fungus produces different enzymes (cellulase, laccase, phenoloxidase, and peroxidases) in the presence of different substrates. At the concentration of 0.3g/L after 6 day 0.76 and 0.78 (cm/day) respectively for Orange G, Reactive blue 4 and Congo red. The study reveals the opportunity of using this yet poorly known fungus for discoloration of synthetic dyes.