Mechanical welding technology has been widely employed in the making of bonding joints with wood. Moso bamboo, a lignocellulosic biomaterial, can also be bonded using mechanical welding technology. The surface response methodology was used to define welding parameters yielding optimal joint strength. In the range of this experiment, it was found that the vibration amplitude and the welding pressure both had a significant influence on the performance of the joint, while the welding time did not. The quadratic model was able to significantly fit the actual results and could be used to determine and optimize the bonding strength.