The rggC locus, with a frameshift mutation, is involved in oxidative stress response by Streptococcus thermophilus - Université de Lorraine Accéder directement au contenu
Article Dans Une Revue Archives of Microbiology Année : 2006

The rggC locus, with a frameshift mutation, is involved in oxidative stress response by Streptococcus thermophilus

Résumé

In Streptococcus thermophilus, the locus rggC contains a frameshift mutation and thus consists of two open reading frames (ORFs), rggC 1 and rggC 2 , which encode proteins exhibiting similarity with the Rgg transcriptional regulator family. In this work, mutants showing a partial deletion of rggC 1 and rggC 2 were constructed and their response to menadione, a superoxide-generating compound, was analysed. These mutants exhibited different behaviour to this oxidative stress compared with the wild-type strain. Analysis of this locus among 21 strains of S. thermophilus showed a polythymine tract length variability and a strain-dependant adenine residue could be found upstream of this repeat. This interstrain polymorphism supports evidence for the hypothesis that the rggC locus is phase variable.
Fichier principal
Vignette du fichier
Fernandez et al ArchMicr-2006-0032.pdf (244.37 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-01631247 , version 1 (09-11-2017)

Identifiants

Citer

Annabelle Fernandez, Frédéric Borges, Brigitte Gintz, Bernard Decaris, Nathalie N. Leblond-Bourget. The rggC locus, with a frameshift mutation, is involved in oxidative stress response by Streptococcus thermophilus. Archives of Microbiology, 2006, 186 (3), pp.161 - 169. ⟨10.1007/s00203-006-0130-8⟩. ⟨hal-01631247⟩
256 Consultations
210 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More