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The rggC locus, with a frameshift mutation, is involved in oxidative stress response by Streptococcus thermophilus

Abstract : In Streptococcus thermophilus, the locus rggC contains a frameshift mutation and thus consists of two open reading frames (ORFs), rggC 1 and rggC 2 , which encode proteins exhibiting similarity with the Rgg transcriptional regulator family. In this work, mutants showing a partial deletion of rggC 1 and rggC 2 were constructed and their response to menadione, a superoxide-generating compound, was analysed. These mutants exhibited different behaviour to this oxidative stress compared with the wild-type strain. Analysis of this locus among 21 strains of S. thermophilus showed a polythymine tract length variability and a strain-dependant adenine residue could be found upstream of this repeat. This interstrain polymorphism supports evidence for the hypothesis that the rggC locus is phase variable.
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Fernandez et al ArchMicr-2006-...
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Annabelle Fernandez, Frédéric Borges, Brigitte Gintz, Bernard Decaris, Nathalie Leblond-Bourget. The rggC locus, with a frameshift mutation, is involved in oxidative stress response by Streptococcus thermophilus. Archives of Microbiology, Springer Verlag, 2006, 186 (3), pp.161 - 169. ⟨10.1007/s00203-006-0130-8⟩. ⟨hal-01631247⟩



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