Towards calixarene-based prodrugs: Drug release and antibacterial behaviour of a water-soluble nalidixic acid/calix[4]arene ester adduct - Archive ouverte HAL Access content directly
Journal Articles Bioorganic and Medicinal Chemistry Letters Year : 2009

Towards calixarene-based prodrugs: Drug release and antibacterial behaviour of a water-soluble nalidixic acid/calix[4]arene ester adduct

(1) , (1) , (1) , (2) , (1) , (1) , (1) , (1)
1
2

Abstract

A water-soluble calixarene-based heterocyclic podand incorporating a quinolone antibiotic subunit, the nalidixic acid, was synthesised and fully characterised. Its prodrug behaviour was assessed in vitro by HPLC, demonstrating the release of the tethered quinolone in model biological conditions. Microbiological studies performed on various Gram-positive and Gram-negative reference strains showed very interesting antibacterial activities.
Not file

Dates and versions

hal-01651216 , version 1 (28-11-2017)

Identifiers

Cite

Hugues Massimba Dibama, Igor Clarot, Stéphane Fontanay, Adel Ben Salem, Maxime Mourer, et al.. Towards calixarene-based prodrugs: Drug release and antibacterial behaviour of a water-soluble nalidixic acid/calix[4]arene ester adduct. Bioorganic and Medicinal Chemistry Letters, 2009, 19 (10), pp.2679 - 2682. ⟨10.1016/j.bmcl.2009.03.139⟩. ⟨hal-01651216⟩
87 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More