Towards calixarene-based prodrugs: Drug release and antibacterial behaviour of a water-soluble nalidixic acid/calix[4]arene ester adduct

Abstract : A water-soluble calixarene-based heterocyclic podand incorporating a quinolone antibiotic subunit, the nalidixic acid, was synthesised and fully characterised. Its prodrug behaviour was assessed in vitro by HPLC, demonstrating the release of the tethered quinolone in model biological conditions. Microbiological studies performed on various Gram-positive and Gram-negative reference strains showed very interesting antibacterial activities.
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Bioorganic & Medicinal Chemistry Letters, Elsevier, 2009, 19 (10), pp.2679 - 2682. 〈10.1016/j.bmcl.2009.03.139〉
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https://hal.univ-lorraine.fr/hal-01651216
Contributeur : Raphaël Duval <>
Soumis le : mardi 28 novembre 2017 - 17:52:29
Dernière modification le : jeudi 25 janvier 2018 - 11:51:01

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Hugues Massimba Dibama, Igor Clarot, Stéphane Fontanay, Adel Ben Salem, Maxime Mourer, et al.. Towards calixarene-based prodrugs: Drug release and antibacterial behaviour of a water-soluble nalidixic acid/calix[4]arene ester adduct. Bioorganic & Medicinal Chemistry Letters, Elsevier, 2009, 19 (10), pp.2679 - 2682. 〈10.1016/j.bmcl.2009.03.139〉. 〈hal-01651216〉

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