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Hypervariability, a New Phenomenon of Genetic Instability, Related to DNA Amplification in Streptomyces ambofaciens

Abstract : The wild-type strain Streptomyces ambofaciens DSM 40697 exhibits a high degree of genetic instability. Pigment-defective colonies were observed in the progeny of wild-type colonies at a frequency of about 0.01. While only 13% of these pigment-defective colonies gave rise to homogeneous progeny exhibiting the mutant parental phenotype, 87% of the mutant colonies gave rise to heterogeneous progeny without a preponderant phenotype. This new phenomenon of instability was called hypervariability. In addition, 21% of the mutant strains arising in hypervariable progeny contained highly reiterated DNA sequences, while amplified DNA sequences could be detected in neither stable pigment-defective mutant clones nor in wild-type clones. These results indicate a frequent association between genetic instability and hypervariability and a frequent association between hypervariability and amplification of DNA sequences.
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Pierre Leblond, Philippe Demuyter, Laurence Moutier, Mohamed Laakel, Bernard Decaris, et al.. Hypervariability, a New Phenomenon of Genetic Instability, Related to DNA Amplification in Streptomyces ambofaciens . Journal of Bacteriology, American Society for Microbiology, 1989, 171 (1), pp.419-423. ⟨10.1128/jb.171.1.419-423.1989⟩. ⟨hal-01658652⟩

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