Hypervariability, a New Phenomenon of Genetic Instability, Related to DNA Amplification in Streptomyces ambofaciens - Université de Lorraine Accéder directement au contenu
Article Dans Une Revue Journal of Bacteriology Année : 1989

Hypervariability, a New Phenomenon of Genetic Instability, Related to DNA Amplification in Streptomyces ambofaciens

Résumé

The wild-type strain Streptomyces ambofaciens DSM 40697 exhibits a high degree of genetic instability. Pigment-defective colonies were observed in the progeny of wild-type colonies at a frequency of about 0.01. While only 13% of these pigment-defective colonies gave rise to homogeneous progeny exhibiting the mutant parental phenotype, 87% of the mutant colonies gave rise to heterogeneous progeny without a preponderant phenotype. This new phenomenon of instability was called hypervariability. In addition, 21% of the mutant strains arising in hypervariable progeny contained highly reiterated DNA sequences, while amplified DNA sequences could be detected in neither stable pigment-defective mutant clones nor in wild-type clones. These results indicate a frequent association between genetic instability and hypervariability and a frequent association between hypervariability and amplification of DNA sequences.
Fichier principal
Vignette du fichier
J. Bacteriol.-1989-Leblond-419-23.pdf (1.65 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-01658652 , version 1 (07-12-2017)

Identifiants

Citer

Pierre Leblond, Philippe Demuyter, Laurence Moutier, Mohamed Laakel, Bernard Decaris, et al.. Hypervariability, a New Phenomenon of Genetic Instability, Related to DNA Amplification in Streptomyces ambofaciens . Journal of Bacteriology, 1989, 171 (1), pp.419-423. ⟨10.1128/jb.171.1.419-423.1989⟩. ⟨hal-01658652⟩
59 Consultations
101 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More