A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics

Abstract : Genetic predictors of beta-lactam (BL) allergy are mostly related to Immunoglobulin E (IgE) synthesis and atopy. Despite this context, little attention has been devoted to genes of IgE/Fc epsilon RI pathway, such as galectin-3, a beta-galactoside-binding lectin, which binds to IgE. We evaluated the association of LGALS3 polymorphisms with BL allergy in 395 Spanish and 198 Italian cases, compared with 310- and 339-matched controls, respectively. The rs11125 predicted BL allergy with an odds ratio of 4.0 in Spanish population (P<0.0001). This association was replicated with an odds ratio of 5.1 in Italian population (P<0.0001); rs11125 predicted also increased serum level of total IgE in Spanish controls. These data are consistent with the predicted deleterious influence of Gln>His substitution produced by rs11125 on galactose-binding activity of galectin-3. In conclusion, LGALS3 is the strongest genetic predictor of BL allergy reported so far. This association reflects the influence of genes of IgE/Fc epsilon RI pathway in this pathology.
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Pharmacogenomics Journal, Nature Publishing Group, 2016, 16 (1), pp.79-82. 〈10.1038/tpj.2015.24〉
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https://hal.univ-lorraine.fr/hal-01659107
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Soumis le : vendredi 8 décembre 2017 - 10:08:40
Dernière modification le : lundi 23 avril 2018 - 15:53:42

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J. A. Cornejo-Garcia, A. Romano, R. M. Gueant-Rodriguez, A. Oussalah, N. Blanca-Lopez, et al.. A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics. Pharmacogenomics Journal, Nature Publishing Group, 2016, 16 (1), pp.79-82. 〈10.1038/tpj.2015.24〉. 〈hal-01659107〉

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