Skip to Main content Skip to Navigation
Journal articles

Biologic agents for IBD: practical insights

Abstract : Six biologic agents are currently approved for the treatment of IBD: four anti-TNF agents (infliximab, adalimumab, golimumab and certolizumab pegol) and two anti-integrin agents (natalizumab and vedolizumab). In Crohn's disease and ulcerative colitis refractory to standard medications, treatment choice among available biologic agents can be challenging. Several parameters should be taken into account to help physicians through the decision-making process, including the comparative effectiveness and long-term safety profile, availability and labelling in the prescriber's country, international guidelines, and cost, as well as patient preferences (such as the route of administration). Herein, we provide practical insights on the use of biologic agents in IBD. The results of head-to-head trials between biologic agents are eagerly awaited to guide decision-making regarding the choice of first-line biologic agents and to determine whether switching within the same drug class or swapping (switching out of the drug class) is preferable after primary or secondary loss of response to the first biologic agent. In the near future, treatment algorithms might evolve with the launch of new drugs (such as ustekinumab, tofacitinib and etrolizumab) and the increased use of biosimilars.
Document type :
Journal articles
Complete list of metadata

https://hal.univ-lorraine.fr/hal-01667747
Contributor : Ngere Ul <>
Submitted on : Tuesday, December 19, 2017 - 3:29:52 PM
Last modification on : Tuesday, October 13, 2020 - 10:46:27 AM

Identifiers

Collections

Citation

Silvio Danese, Lucine Vuitton, Laurent Peyrin-Biroulet. Biologic agents for IBD: practical insights. Nature reviews. Gastroenterology & hepatology, Nature Publishing Group, 2009-, 2015, 12 (9), pp.537 - 545. ⟨10.1038/nrgastro.2015.135⟩. ⟨hal-01667747⟩

Share

Metrics

Record views

165