Galectin-3: A key player in arthritis - Université de Lorraine Access content directly
Journal Articles Joint Bone Spine Year : 2017

Galectin-3: A key player in arthritis

Abstract

Arthritis is more and more considered as the leading reason for the disability in the world, particularly regarding its main entities, rheumatoid arthritis and osteoarthritis. The common feature of arthritis is inflammation, which is mainly supported by synovitis (synovial inflammation), although the immune system plays a primary role in rheumatoid arthritis and a secondary one in osteoarthritis. During the inflammatory phase of arthritis, many pro-inflammatory cytokines and mediators are secreted by infiltrating immune and resident joint cells, which are responsible for cartilage degradation and excessive bone remodeling. Amongst them, a β-galactoside-binding lectin, galectin-3, has been reported to be highly expressed and secreted by inflamed synovium of rheumatoid arthritis and osteoarthritis patients. Furthermore, galectin-3 has been demonstrated to induce joint swelling and osteoarthritis-like lesions after intra-articular injection in laboratory animals. However, the mechanisms underlying its pathophysiological role in arthritis have not been fully elucidated. This review deals with the characterization of arthritis features and galectin-3 and summarizes our current knowledge of the contribution of galectin-3 to joint tissue lesions in arthritis.
Fichier principal
Vignette du fichier
Version_Hal_JBS_Victor.pdf (429.46 Ko) Télécharger le fichier
Origin Files produced by the author(s)

Dates and versions

hal-01704704 , version 1 (08-02-2022)

Licence

Identifiers

Cite

Yong Hu, Mélissa Yéléhé-Okouma, Hang-Korng Ea, Jean-Yves Jouzeau, Pascal Reboul. Galectin-3: A key player in arthritis. Joint Bone Spine, 2017, 84 (1), pp.15-20. ⟨10.1016/j.jbspin.2016.02.029⟩. ⟨hal-01704704⟩
156 View
368 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More