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Effect of retinoic acid on two glycosyltransferase activities in c6 cultured glioma cells

Abstract : 1. Activity of two glycosyltransferases was studied in retinoic acid-treated C6 cultured glioma cells. 2. The beta-galactoside alpha 2,3-sialyltransferase transferring N-acetylneuramin onto the O-glycans residues of glycoproteins was activated up to twice after chronic treatment (from 24 to 96 hr) with all-trans retinoic acid. 3. No effect was observed for shorter treatments. 4. On the opposite, the N-glycan galactosyltransferase activity remained unchanged whatever the length of retinoic acid treatment was. 5. The activatory effect was not dependent on isomery, as all-trans and 13-cis retinoic acid isomers were both activators of the C6 glioma cell sialyltransferase. 6. Measurement of adhesion of retinoic acid-treated cells using labelled plasma membranes showed an enhancement of adhesion in correlation with enhancement of sialyltransferase activity.
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https://hal.univ-lorraine.fr/hal-01705242
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Submitted on : Friday, February 9, 2018 - 11:20:52 AM
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Pascal Reboul, Pierre Broquet, Pascal George, Pierre Louisot. Effect of retinoic acid on two glycosyltransferase activities in c6 cultured glioma cells. The International journal of biochemistry, Elsevier, 1990, 22 (8), pp.889 - 893. ⟨10.1016/0020-711X(90)90293-C⟩. ⟨hal-01705242⟩

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