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Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs

Abstract : Dual 5-LOX/COX inhibitors are potential new drugs to treat inflammation. They act by blocking the formation of both prostaglandins and leucotrienes but do not affect lipoxin formation. Such combined inhibition avoids some of the disadvantages of selective COX-2 inhibitors and spares the gatrointestinal mucosa.
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https://hal.univ-lorraine.fr/hal-01705863
Contributor : Pascal Reboul <>
Submitted on : Friday, February 9, 2018 - 9:39:29 PM
Last modification on : Monday, July 20, 2020 - 12:33:14 PM

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Johanne Martel-Pelletier, Daniel Lajeunesse, Pascal Reboul, Jean-Pierre Pelletier. Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs. Annals of the Rheumatic Diseases, BMJ Publishing Group, 2003, 62 (6), pp.501 - 509. ⟨10.1136/ard.62.6.501⟩. ⟨hal-01705863⟩

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