Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs - Université de Lorraine Access content directly
Journal Articles Annals of the Rheumatic Diseases Year : 2003

Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs

Abstract

Dual 5-LOX/COX inhibitors are potential new drugs to treat inflammation. They act by blocking the formation of both prostaglandins and leucotrienes but do not affect lipoxin formation. Such combined inhibition avoids some of the disadvantages of selective COX-2 inhibitors and spares the gatrointestinal mucosa.

Dates and versions

hal-01705863 , version 1 (09-02-2018)

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Johanne Martel-Pelletier, Daniel Lajeunesse, Pascal Reboul, Jean-Pierre Pelletier. Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs. Annals of the Rheumatic Diseases, 2003, 62 (6), pp.501 - 509. ⟨10.1136/ard.62.6.501⟩. ⟨hal-01705863⟩

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