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Influence of muramyl dipeptide on established experimental arthritis in rats.

Abstract : The effects of MDP, a potent inducer of cytokines, were studied in four batches of Wistar Furth rats with established experimental arthritis. Arthritic rats were given a daily sc injection of 10, 100, 200 or 400 micrograms MDP respectively. Muramyl dipeptide increased the severity of clinical events in a dose-dependent manner, with the exception of the 10 micrograms dose which was ineffective. The levels of anti-collagen antibodies were not however significantly enhanced by MDP. Radiological lesions and histological changes were maximal at high dosage regimens. Paradoxically, the acute phase reactive alpha 1 glycoprotein was little affected by MDP treatment.
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https://hal.univ-lorraine.fr/hal-01707374
Contributor : Jean-Yves Jouzeau <>
Submitted on : Monday, February 12, 2018 - 5:20:20 PM
Last modification on : Friday, September 17, 2021 - 12:30:12 PM

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  • HAL Id : hal-01707374, version 1
  • PUBMED : 2069088

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J Jouzeau, E Drelon, G. Gillet, B Bannwarth, P. Fener, et al.. Influence of muramyl dipeptide on established experimental arthritis in rats.. Agents and actions. Supplements, 1991, pp.191-5. ⟨hal-01707374⟩

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