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Biphasic airway–lung response to anaphylactic shock in Brown Norway rats

Abstract : Bronchospasm may be part of the response to systemic anaphylaxis in humans. The anaphylactic shock has been characterized in allergic rats, but little data are available on the concurrent changes in airway–lung mechanics. The aim was to describe the respiratory resistance (Rrs) and reactance (Xrs) response to ovalbumin (OVA) induced systemic anaphylaxis in allergic rats. Thirty five anesthetized and mechanically ventilated Brown Norway rats were randomly allocated to OVA (n = 20) or vehicle (n = 15) sensitization and provocation. Rrs and Xrs were obtained by the forced oscillation technique at 20 Hz. Allergic rats showed dramatic and reproducible concurrent Rrs peak and Xrs through within 4 min of OVA injection (p < 0.0001). Thereafter, Rrs returned to baseline while Xrs remained significantly more negative (p < 0.0001). It is concluded that systemic anaphylaxis in allergic rats is associated with severe early acute inhomogeneous bronchoconstriction followed by pulmonary interstitial/small airspace edema. The model may be of interest to assess treatments targeting the associated bronchoconstriction and/or airway vascular leakage.
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https://hal.univ-lorraine.fr/hal-01708940
Contributor : Devah Ul Connect in order to contact the contributor
Submitted on : Wednesday, February 14, 2018 - 12:04:19 PM
Last modification on : Tuesday, December 7, 2021 - 4:46:02 PM

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G. Barthel, F. Zheng, B. Demoulin, J. Davidson, C. Montémont, et al.. Biphasic airway–lung response to anaphylactic shock in Brown Norway rats. Respiratory Physiology and Neurobiology, Elsevier, 2013, 189 (1), pp.47 - 51. ⟨10.1016/j.resp.2013.07.003⟩. ⟨hal-01708940⟩

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