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Evidence of Cyclic Changes in the Metabolism of Abdominal Aortic Aneurysms During Growth Phases: 18F-FDG PET Sequential Observational Study

Abstract : The rates of growth of medically treated abdominal aortic aneurysms (AAA) are difficult to determine, and relationships with parietal inflammation and with metabolic parameters from (18)F-FDG PET remain unclear. This (18)F-FDG PET sequential observational study was aimed at analyzing the metabolic changes accompanying the growth phases of medically treated AAA. METHODS: Thirty-nine patients (37 men; age [mean ± SD], 71 ± 12 y) exhibiting small and medically treated AAA (maximal diameter, 46 ± 3 mm) underwent (18)F-FDG PET and CT angiography at baseline and 9 mo later. Clinical and imaging parameter correlates of the 9-mo increase in maximal diameter were investigated; these included (18)F-FDG maximal standardized uptake values (SUVmax) averaged for slices encompassing the AAA volume. RESULTS: Of the 39 patients, 9 (23%) had a significant (≥2.5 mm) increase in maximal diameter at 9 mo, whereas the remaining 30 did not. The patients with an increase in maximal diameter at 9 mo exhibited lower SUVmax within the AAA at baseline than patients who did not have such an increase (1.80 ± 0.45 vs. 2.21 ± 0.52; P = 0.04); they also displayed a trend toward greater changes in SUVmax at 9 mo (difference between 9 mo and baseline: +0.40 ± 0.85 vs. -0.06 ± 0.57; P = 0.07). Similar levels were ultimately reached in both groups at 9 mo (2.20 ± 0.83 and 2.15 ± 0.66). SUVmax was a significant, yet modest, baseline predictor of the absolute change in maximal diameter during follow-up (P = 0.049). CONCLUSION: The enhancement in the maximal diameter of small AAA was preceded by a stage with a low level of (18)F-FDG uptake, but this low level of uptake was no longer documented after the growth phases, suggesting a pattern of cyclic metabolic changes.
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https://hal.univ-lorraine.fr/hal-01730651
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Submitted on : Tuesday, March 13, 2018 - 2:36:06 PM
Last modification on : Saturday, October 16, 2021 - 11:18:08 AM

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Olivier Morel, Damien Mandry, Emilien Micard, Claude Kauffmann, Zohra Lamiral, et al.. Evidence of Cyclic Changes in the Metabolism of Abdominal Aortic Aneurysms During Growth Phases: 18F-FDG PET Sequential Observational Study. Journal of Nuclear Medicine, Society of Nuclear Medicine, 2015, 56 (7), pp.1030 - 1035. ⟨10.2967/jnumed.114.146415⟩. ⟨hal-01730651⟩

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