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Master thesis

Dépistage du cancer des reins natifs chez les transplantés rénaux: évaluation des pratiques nancéennes

Abstract : With the progress done in immunosuppressive therapies, and in the care of kidney transplant recipients, the survival of the graft gets longer and longer. Due to this low immunity, some neoplasic complications tend to occur, such as renal cell carcinoma of the native kidneys. The screening with ultrasound of the kidneys is known to be difficult, thus we suggested screening with computed tomography starting the third year post transplantation, and then every other year. The purpose of this study is to evaluate the incidence of renal cell carcinoma in kidney transplant recipients, and to determine if computed tomography is more efficient than ultrasound. 711 patients have been included in this study, amongst whom 19 have developed renal cell carcinoma. Nine of them belong to the group screened with ultrasound, and ten of them were screened with computed tomography. The time spent on dialysis, the time between the transplantation and the diagnosis of cancer, and the size of the tumours once the diagnosis is set, are not different in the two groups. We can notice in this study an increased incidence of renal cell carcinoma in the transplant population, in contrast with the general population. However the number of cancer screened with computed tomography is not significantly higher than the one screened with ustrasound. Regarding the imputability of the immunosuppression in this increased incidence, it is not the only cause, as patients with chronic renal failure, and patients on dialysis, also present a higher risk of developing renal cell carcinoma. The prognosis of suchtumour is good, since the survival rate reaches 92% after five years.
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Master thesis
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  • HAL Id : hal-01731703, version 1


Emmanuelle Kohler. Dépistage du cancer des reins natifs chez les transplantés rénaux: évaluation des pratiques nancéennes. Sciences du Vivant [q-bio]. 2010. ⟨hal-01731703⟩



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