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Master thesis

Ablation par radiofréquence de fibrillation atriale, expérience Nancéenne, intérêt de bio-marqueurs prédictifs de réussite.

Abstract : BACKGROUND AND OBJECTIVES: Catheter ablation for atrial fibrillation (AF) has proved to be quite effective in maintaining sinus rhythm without ant-arrhythmic drugs (AA). This procedure has been followed for more than 10 years in our hospital. The aim of our study was to compare our results after one year of follow up with those of other recent publications, and to find the adequate biomarkers of the relevance of this procedure. METHODS: We followed a cohort of 335 consecutive patients with primary ablation between May 2009 and May 2011. A total of 475 ablations were performed: 54% paroxysmal AF, 30% persistent AF, 16% Long standing Persistent AF, Structural heart disease 30%. The bio-markers we evaluated were BNP, CRP and left atrium (LA) volume. RESULTS: After AF procedure sinus rhythm is maintained in 56% after one year follow up for paroxysmal AF, 46% for persistent and 22% for Longstanding Persistent. A major complication (pericardial effusion requiring surgical drainage) occurred in 1,05%. No thrombo-embolic event was reported. There was a good correlation between the success of the procedure and the levels of BNP and CRP, and the LA volume, especially for paroxysmal AF (BNP<50ng/ml OR=4, LA volume < 50ml OR=8, CRP<2mg/l OR=2.4) CONCLUSION: The results of our hospital are in agreement with those of experienced centers. BNP and atrial volume appear interesting as predictive markers for successful ablation.
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https://hal.univ-lorraine.fr/hal-01731965
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Arnaud Olivier. Ablation par radiofréquence de fibrillation atriale, expérience Nancéenne, intérêt de bio-marqueurs prédictifs de réussite.. Sciences du Vivant [q-bio]. 2012. ⟨hal-01731965⟩

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