Skip to Main content Skip to Navigation
Master thesis

Résultats à long terme de l'infliximab chez les patients présentant des lésions ano-périnéales non fistulisantes de maladie de Crohn

Abstract : Background: ln Crohn's disease, anal ulceration and stricture can be disabling.Aim : To evaluate long-tenn outcome of non-fistulizing perianal Crohn' s disease under infliximab.Methods : The medical records of99 patients with non-fistulizing perianal Crohn's disease at first infliximab infusion were reviewed. Complete responses (ulceration healing or stricture regression) after induction infliximab therapy and at the maximal follow-up were assessed.Results : Ninety-four patients (94.9%) had ulceration, 22 (22.2%) had stricture and 31 (3 1.3%) had draining perianal fistulas at first infliximab infusion. After infliximab induction therapy, 40/94 (42.5%) patients with ulceration, 4/22 (18.2%) with stricture and 10/31 (32.2%) with fistulas had a complete response. Eight patients were lost to follow-up. After a median follow-up of 175 weeks (range, 13-459), complete response rates for ulceration, stricture and fistulas were 72.3% (68/94), 54.5% (12/22) and 54.8% (20/3 1), respec tively. Long-term response for cavitating ulcer was positively associa ted with concomitant immunosuppressant use (P=O.O 17) and older age (P=0.049) . Among the 12 patients with complete regression of stricture, 6 patients also had anal dilatation. Complete response was associa ted with perianal pain relief and disappearance of soiling. Three patients with ulceration developed an anal abscess.Conclusions : Infliximab therapy may be effective in inducing and maintaining response for ulceration.
Document type :
Master thesis
Complete list of metadata

Cited literature [42 references]  Display  Hide  Download

https://hal.univ-lorraine.fr/hal-01733341
Contributor : Colette Orange <>
Submitted on : Wednesday, March 14, 2018 - 3:47:20 PM
Last modification on : Friday, October 23, 2020 - 4:58:49 PM
Long-term archiving on: : Wednesday, September 5, 2018 - 2:57:30 AM

File

SCDMED_T_2009_TROUILLOUD_ISABE...
Files produced by the author(s)

Identifiers

  • HAL Id : hal-01733341, version 1

Citation

Isabelle Trouilloud. Résultats à long terme de l'infliximab chez les patients présentant des lésions ano-périnéales non fistulisantes de maladie de Crohn. Sciences du Vivant [q-bio]. 2009. ⟨hal-01733341⟩

Share

Metrics

Record views

14

Files downloads

51