Skip to Main content Skip to Navigation
Master thesis

Analyse quantitative de la tomoscintigraphie par émission de positions au 18[indice]F-FDG dans l'épilepsie temporale pharmacorésistance : comparaison de deux méthodes de normalisation spatiale

Abstract : PURPOSE : cerebral 18F-FDG-PET is often used in the pre-surgical work up of drug refractory temporal lobe epilepsy. Voxel-by-voxel quantitative statistical analysis with control populations are increasingly used in arder to make the interpretation of these exams easier. SPM is the reference method, using a normalization process but with some issues (abnormal images deformations and unsuitable anatomical template). We compared the SPM procedure with a new INRIA-developed spatial normalization method which could be able to, at leastpartially, overcome these SPM issues. METHODS : INRIA method was less sensible than SPM in the detection of temporal epileptogenic foci (73% vs 93%) but seemed to bring more specific results since it detected less extra-cerebral abnormalities with a slightly better normality rate in the control population (85% vs 69%).CONCLUSION : in cerebral 18F-FDG-PET performed in the temporal lobe epilepsy work-up, abnormalities quantification with the new INRIA-developed method seems to bring a better specifity, maybe at the price of a lower sensibility. Ongoing studies are conducted to optimize this new method.
Document type :
Master thesis
Complete list of metadata

https://hal.univ-lorraine.fr/hal-01734337
Contributor : Colette Orange <>
Submitted on : Wednesday, March 14, 2018 - 4:34:35 PM
Last modification on : Monday, October 19, 2020 - 11:10:25 AM
Long-term archiving on: : Wednesday, September 5, 2018 - 2:06:54 PM

File

SCDMED_T_2009_GILLET_NICOLAS.p...
Files produced by the author(s)

Identifiers

  • HAL Id : hal-01734337, version 1

Citation

Nicolas Gillet. Analyse quantitative de la tomoscintigraphie par émission de positions au 18[indice]F-FDG dans l'épilepsie temporale pharmacorésistance : comparaison de deux méthodes de normalisation spatiale. Sciences du Vivant [q-bio]. 2009. ⟨hal-01734337⟩

Share

Metrics

Record views

29

Files downloads

170