Metabolic syndrome, abdominal obesity and hyperuricemia in schizophrenia: Results from the FACE-SZ cohort
O. Godin
(1, 2)
,
M. Leboyer
(1, 3, 4)
,
A. Gaman
(1)
,
Bruno Aouizerate
(1, 5, 6)
,
Fabrice Berna
(1, 7, 8)
,
L. Brunel
(1, 3, 4)
,
D. Capdevielle
(1, 9, 10)
,
I. Chereau
(1, 11)
,
M. Dorey
(1, 12, 13)
,
C. Dubertret
(1, 14, 15)
,
J. Dubreucq
(1, 16)
,
C. Faget
(1, 17)
,
F. Gabayet
(1, 16)
,
Y. Le Strat
(14, 1, 15)
,
P. Llorca
(11, 1)
,
D. Misdrahi
(1, 18, 5)
,
R. Rey
(1, 12, 13)
,
R. Richieri
(1, 17)
,
C. Passerieux
(1, 19, 20)
,
A. Schandrin
(1, 9, 10)
,
F. Schürhoff
(1, 3, 4)
,
M. Urbach
(1, 19, 20)
,
P. Vidalhet
(7, 8)
,
N. Girerd
(21, 22)
,
G Fond
(1, 3, 4)
1
Fondation FondaMental [Créteil]
2 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
3 IMRB - Institut Mondor de Recherche Biomédicale
4 DHU PePsy - Psychiatrie et Neurologie personnalisées [AP-HP Hôpital Henri-Mondor]
5 Centre hospitalier Charles Perrens [Bordeaux]
6 Physiopathologie du système nerveux central - Institut François Magendie
7 NCPS - Neuropsychologie Cognitive et Physiopathologie de la Schizophrénie
8 FMTS - Fédération de Médecine Translationnelle de Strasbourg
9 Hôpital la Colombière [CHU Montpellier]
10 PSNREC - Neuropsychiatrie : recherche épidémiologique et clinique
11 NPsy-Sydo - Neuro-Psycho Pharmacologie des Systèmes Dopaminergiques sous-corticaux
12 UCBL - Université Claude Bernard Lyon 1
13 Centre Hospitalier le Vinatier [Bron]
14 U894 - Centre de Psychiatrie et Neurosciences
15 Hôpital Louis Mourier - AP-HP [Colombes]
16 Centre Référent de Réhabilitation Psychosociale [CH Alpes Isère]
17 Hôpitaux Sud - Département Universitaire de Psychiatrie - [Hôpital Sainte Marguerite - APHM]
18 INCIA - Institut de Neurosciences cognitives et intégratives d'Aquitaine
19 CHV - Centre Hospitalier de Versailles André Mignot
20 UVSQ Santé - UFR Sciences de la santé Simone Veil
21 CIC-P - Centre d'investigation clinique plurithématique Pierre Drouin [Nancy]
22 DCAC - Défaillance Cardiovasculaire Aiguë et Chronique
2 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
3 IMRB - Institut Mondor de Recherche Biomédicale
4 DHU PePsy - Psychiatrie et Neurologie personnalisées [AP-HP Hôpital Henri-Mondor]
5 Centre hospitalier Charles Perrens [Bordeaux]
6 Physiopathologie du système nerveux central - Institut François Magendie
7 NCPS - Neuropsychologie Cognitive et Physiopathologie de la Schizophrénie
8 FMTS - Fédération de Médecine Translationnelle de Strasbourg
9 Hôpital la Colombière [CHU Montpellier]
10 PSNREC - Neuropsychiatrie : recherche épidémiologique et clinique
11 NPsy-Sydo - Neuro-Psycho Pharmacologie des Systèmes Dopaminergiques sous-corticaux
12 UCBL - Université Claude Bernard Lyon 1
13 Centre Hospitalier le Vinatier [Bron]
14 U894 - Centre de Psychiatrie et Neurosciences
15 Hôpital Louis Mourier - AP-HP [Colombes]
16 Centre Référent de Réhabilitation Psychosociale [CH Alpes Isère]
17 Hôpitaux Sud - Département Universitaire de Psychiatrie - [Hôpital Sainte Marguerite - APHM]
18 INCIA - Institut de Neurosciences cognitives et intégratives d'Aquitaine
19 CHV - Centre Hospitalier de Versailles André Mignot
20 UVSQ Santé - UFR Sciences de la santé Simone Veil
21 CIC-P - Centre d'investigation clinique plurithématique Pierre Drouin [Nancy]
22 DCAC - Défaillance Cardiovasculaire Aiguë et Chronique
O. Godin
- Function : Author
- PersonId : 1093297
- IdHAL : ophelia-godin
- ORCID : 0000-0001-5004-5475
M. Leboyer
- Function : Author
- PersonId : 756830
- ORCID : 0000-0001-5473-3697
- IdRef : 089352475
Bruno Aouizerate
- Function : Author
- PersonId : 751079
- IdHAL : bruno-aouizerate
- ORCID : 0000-0002-7092-7747
- IdRef : 069471851
Fabrice Berna
- Function : Author
- PersonId : 1247289
- ORCID : 0000-0002-6118-0629
- IdRef : 113479174
D. Capdevielle
- Function : Author
- PersonId : 1416394
- ORCID : 0000-0002-7146-8554
- IdRef : 069470251
Y. Le Strat
- Function : Author
- PersonId : 907941
D. Misdrahi
- Function : Author
- PersonId : 1033225
- ORCID : 0000-0003-1146-3206
- IdRef : 091552125
C. Passerieux
- Function : Author
- PersonId : 1234382
- ORCID : 0000-0003-4130-1590
A. Schandrin
- Function : Author
- PersonId : 1124624
G Fond
- Function : Author
- PersonId : 767238
- ORCID : 0000-0003-3249-2030
- IdRef : 15207127X
Abstract
OBJECTIVE:
Abdominal obesity was suggested to be a better predictor than Metabolic Syndrome (MetS) for cardiovascular mortality, however this is has not been extensively studied in schizophrenia. Hyperuricemia (HU) was also suggested to be both an independent risk factor for greater somatic comorbidity and a global metabolic stress marker in patients with schizophrenia. The aim of this study was to estimate the prevalence of MetS, abdominal obesity and HU, to examine the association between metabolic parameters with HU in a cohort of French patients with schizophrenia or schizo-affective disorder (SZ), and to estimate the prevalence rates of treatment of cardio-vascular risk factors.
METHOD:
240 SZ patients (age=31.4years, male gender 74.3%) were systematically included. Metabolic syndrome was defined according to the International Diabetes Federation and HU if serum uric acid level was above 360μmol/L.
RESULTS:
MetS, abdominal obesity and HU were found respectively in 24.2%, 21.3% and 19.6% of patients. In terms of risk factors, multiple logistic regression showed that after taking into account the potential confounders, the risk for HU was higher in males (OR=5.9, IC95 [1.7-21.4]) and in subjects with high waist circumference (OR=3.1, IC95 [1.1-8.3]) or hypertriglyceridemia (OR=4.9, IC95 [1.9-13]). No association with hypertension, low HDL cholesterol or high fasting glucose was observed. Only 10% of patients with hypertension received a specific treatment, 18% for high fasting glucose and 8% for dyslipidemia.
CONCLUSIONS:
The prevalence of MetS, abdominal obesity and hyperuricemia is elevated in French patients with schizophrenia, all of which are considerably under-diagnosed and undertreated. HU is strongly associated with abdominal obesity but not with psychiatric symptomatology.