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Fragmented red cells reference range for the Sysmex XN ® -series of automated blood cell counters

Abstract : INTRODUCTION: Fragmented red cells (FRCs) are a new parameter determined automatically by the latest generation of blood cell counters. FRC counts may be of interest as they may reflect schistocyte counts measured on a stained peripheral blood smear observed under the microscope. However, FRC counts depend on the technical procedure used to detect them so that reference ranges are device dependent. The XN-9000® is one of the latest models from the Sysmex series of analysers. MATERIAL, METHODS AND RESULTS: We aimed to establish a reference range for FRCs based on 1366 normal patient samples. The mean ± SD was 0.14 ± 0.35% and the median was 0% (95% confidence interval of the mean: 0.12-0.16%). We observed that the percentage of red blood cells with <17 pg of haemoglobin content (Hypo-He) was correlated to an FRC increase and that flagged results relating to red blood cells, reticulocytes or platelets might have presented with artefactually increased FRCs. CONCLUSION: The FRCs reference range (healthy subjects) should be useful for laboratory staff for selecting which blood smears to check optically.
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Submitted on : Tuesday, June 12, 2018 - 10:46:54 AM
Last modification on : Tuesday, October 13, 2020 - 10:47:15 AM

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J.-F. Lesesve, E. Speyer, J.-P. Perol. Fragmented red cells reference range for the Sysmex XN ® -series of automated blood cell counters. International Journal of Laboratory Hematology, Wiley, 2015, 37 (5), pp.583 - 587. ⟨10.1111/ijlh.12364⟩. ⟨hal-01813240⟩



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