Étude de la réversion de la résistance aux médicaments anthelminthiques chez le nématode Caenorhabditis elegans

Abstract : Macrocyclic lactones are pharmaceutical drugs used in humans and animals health whose therapeutic success is compromised by the development of resistance. In that context, our objective was characterize the adaptation of the model nematode C. elegans to ML selection pressure. Sensitivities to MLs and to oxidative, thermal and osmotic stress were determined in ML-selected strains after the remove of selection pressure. ML-selected strains were defective in food chemotaxis and were more sensitive to paraquat. After the removal of MLs selection pressure in ML-selected strain, a reversion towards susceptibility for MLs was observed. Moreover, only MOX-selected strain was able to detect food when the drug selection pressure was absent. Otherwise, all the ML-selected strains have their lifespan decreased. This study provides new data about the mechanisms of resistance to MLs and reversion towards susceptibility in the nematode C. elegans.
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Master thesis
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Amandine Goulon. Étude de la réversion de la résistance aux médicaments anthelminthiques chez le nématode Caenorhabditis elegans. Biotechnologies. 2016. ⟨hal-01824829⟩

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