Caractérisation expérimentale des propriétés optiques et rhéologiques de tissus vasculaires : étude en régime statique

Abstract : The study of mechanical properties of the arterial wall is an important step in the comprehension of the vascular physiopathological functioning. Thus, when alterations appear due to aging or eventual pathological vascular diseases (atherosclerosis, hypertension, anevrysm...), medical options and surgical treatments are undertaken to recover a healthy working. One of these surgical technics consists in the remplacement of the defective arterial segment by a cryopreserved vascular allograft. However, cryopreserving biological tissues using very low temperatures can induce biological and structural modifications which may involve complications (dilatation, bursting, stenosis) after reimplantation. Many procedures of mechanical tests (traction, dilatation) developped in research allow us to comprehend and analyse the rheological behaviour of the arterial wall. The study presented in this report offers a new perspective to detect changes of mechanical properties of cryopreserved arterial samples. In fact, the original idea is to couple a mechanical test bed (uniaxial traction of arterial rings) with spectroscopic measurements (autofluorescence, elastic scattering) for the purpose of correlating mechanical modifications and spectral variations. Ultimately, this new approach could lead to develop a device allowing atraumatic and contactless optical examinations of arterial graft to determine its mechanical state before reimplantation.
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Master thesis
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Jean-Christophe Goebel. Caractérisation expérimentale des propriétés optiques et rhéologiques de tissus vasculaires : étude en régime statique. Automatique / Robotique. 2004. ⟨hal-01893160⟩

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