Skip to Main content Skip to Navigation
Journal articles

Bioinspired Nanofeatured Substrates: Suitable Environment for Bone Regeneration

Abstract : Bone mimicking coatings provide a complex microenvironment in which material, through its inherent properties (such as nanostructure and composition), affects the commitment of stem cells into bone lineage and the production of bone tissue regulating factors required for bone healing and regeneration. Herein, a bioactive mineral/biopolymer composite made of calcium phosphate/chitosan and hyaluronic acid (CaP-CHI-HA) was elaborated using a versatile simultaneous spray coating of interacting species. The resulting CaP-CHI-HA coating was mainly constituted of bioactive, carbonated and crystalline hydroxyapatite with 277 ± 98 nm of roughness, 1 μm of thickness, and 2.3 ± 1 GPa of stiffness. After five days of culture, CaP-CHI-HA suggested a synergistic effect of intrinsic biophysical features and biopolymers on stem cell mechanobiology and nuclear organization, leading to the expression of an early osteoblast-like phenotype and the production of bone tissue regulating factors such as osteoprotegerin and vascular endothelial growth factor. More interestingly, amalgamation with biopolymers conferred to the mineral a bacterial antiadhesive property. These significant data shed light on the potential regenerative application of CaP-CHI-HA bioinspired coating in providing a suitable environment for stem cell bone regeneration and an ideal strategy to prevent implant-associated infections.
Document type :
Journal articles
Complete list of metadata
Contributor : Romain Hocquel Connect in order to contact the contributor
Submitted on : Wednesday, December 5, 2018 - 12:46:04 PM
Last modification on : Friday, January 7, 2022 - 3:53:26 AM



H. Rammal, M. Dubus, L. Aubert, F. Reffuveille, D. Laurent-Maquin, et al.. Bioinspired Nanofeatured Substrates: Suitable Environment for Bone Regeneration. ACS Applied Materials & Interfaces, Washington, D.C. : American Chemical Society, 2017, 9 (14), pp.12791-12801. ⟨10.1021/acsami.7b01665⟩. ⟨hal-01945517⟩



Record views