Hepatitis B virus mutations potentially conferring adefovir/tenofovir resistance in treatment-naive patients. - Université de Lorraine Accéder directement au contenu
Article Dans Une Revue World Journal of Gastroenterology Année : 2009

Hepatitis B virus mutations potentially conferring adefovir/tenofovir resistance in treatment-naive patients.

Résumé

Anti-hepatitis B virus (HBV) therapy leads to the emergence of mutant viral strains during the treatment of chronic hepatitis B with nucleos(t)ides analogues. The existence of HBV variants with primary antiviral resistance may be important for treatment choice. We studied two patients with chronic HBV infection by sequencing the HBV polymerase gene. They had adefovir- and tenofovir-related mutations in the viral polymerase, although they had never been treated. These mutations were rtV214A/rtN238T in one patient and rtA194T in the other. Thus, mutations in untreated patients deserve cautious surveillance. These data indicate that mutations that can theoretically confer adefovir or tenofovir resistance may emerge in treatment-naive patients.

Dates et versions

hal-02043721 , version 1 (21-02-2019)

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Rebecca Pastor, François Habersetzer, Samira Fafi-Kremer, Michel Doffoel, Thomas-F Baumert, et al.. Hepatitis B virus mutations potentially conferring adefovir/tenofovir resistance in treatment-naive patients.. World Journal of Gastroenterology, 2009, 15 (6), pp.753-5. ⟨hal-02043721⟩
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