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Nanoparticulate delivery systems for alkyl gallates: Influence of the elaboration process on particle characteristics, drug encapsulation and in-vitro release

Abstract : PLA nanoparticles loaded with n-alkyl gallates (AGs) were prepared either by nanoprecipitation (NP) or by O/W emulsion/solvent evaporation (E/SE). A nonionic hydrophobically modified polysaccharide was used for surface coverage and for ensuring colloidal stability. Different parameters were systematically assessed to enhance the drug incorporation, with the aim of obtaining monomodal and narrow particle size distributions. The nanoparticles were characterized by 1H NMR, transmission electron microscopy (TEM) and laser light scattering granulometry. The colloidal stability of suspensions was evaluated after incubation in NaCl solutions and was maintained up to 1 M NaCl. The mean particle diameter and the width of size distribution were found very similar for both processes (slightly lower diameters when using E/SE) with various drug loadings. The amount of encapsulated AG by E/SE was about twice that encapsulated by NP. The in-vitro release of AG was evaluated under sink conditions and no burst effect was observed. Release curves were successfully modeled using the Fick diffusion model with a constant diffusion coefficient and assuming non-swellable particles. Diffusion coefficients of AG loaded in nanoparticles prepared by NP were higher than those found in nanoparticles elaborated by E/SE
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https://hal.univ-lorraine.fr/hal-02058200
Contributor : Alain Durand Connect in order to contact the contributor
Submitted on : Sunday, January 23, 2022 - 2:30:44 PM
Last modification on : Tuesday, January 25, 2022 - 12:55:15 PM
Long-term archiving on: : Sunday, April 24, 2022 - 6:05:55 PM

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Asma Chebil, Michèle Leonard, Jean-Luc Six, Cécile Nouvel, Alain Durand. Nanoparticulate delivery systems for alkyl gallates: Influence of the elaboration process on particle characteristics, drug encapsulation and in-vitro release. Colloids and Surfaces B: Biointerfaces, Elsevier, 2018, 162, pp.351-361. ⟨10.1016/j.colsurfb.2017.11.050⟩. ⟨hal-02058200⟩

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