New Efficient Synthetic Pathways to Tetrakis{p-[(diethylphosphono)methyl]}calix[4]arene - Université de Lorraine Access content directly
Journal Articles Helvetica Chimica Acta Year : 2012

New Efficient Synthetic Pathways to Tetrakis{p-[(diethylphosphono)methyl]}calix[4]arene

Abstract

Various operating conditions have been applied on tetrakis[p‐(halogenomethyl)]‐ and tetrakis[p‐(aminomethyl)]calix[4]arene derivatives to improve the synthesis of the 5,11,17,23‐tetrakis[(diethylphosphono)methyl]‐25,26,27,28‐tetrahydroxycalix[4]arene. Two new, high yield, synthetic pathways have been selected, involving, for the first one, the 25,26,27,28‐tetrahydroxy‐5,11,17,23‐tetrakis[(trimethylamino)methyl]calix[4]arene, tetraiodide, DMF, and 10 equiv. of triethyl phosphite ((EtO)3P), and, for the other one, the 5,11,17,23‐tetra(bromomethyl)‐25,26,27,28‐tetrahydroxycalix[4]arene, CH2Cl2, and only 4 equiv. of (EtO)2P.

Dates and versions

hal-02086803 , version 1 (01-04-2019)

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Maxime Mourer, Jean-Bernard Regnouf-De-Vains. New Efficient Synthetic Pathways to Tetrakis{p-[(diethylphosphono)methyl]}calix[4]arene. Helvetica Chimica Acta, 2012, 95 (5), pp.766-771. ⟨10.1002/hlca.201100413⟩. ⟨hal-02086803⟩
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