High-Relaxivity Gd(III)–Hemicryptophane Complex
Abstract
The polytopic hemicryptophane cage HC1 combining a cyclotriveratrylene (CTV) unit and a tris(2- aminoethyl)amine (tren) moiety connected by three 2- hydroxyisophthalamide linkers was synthesized in 12 steps.
The resulting highly functionalized covalent host is soluble in aqueous medium and has been used to complex Gd(III) ion.
The Gd(III)@HC1 complex presents promising relaxivity properties when compared to the clinically used Dotarem MRI agent.
| Origin | Files produced by the author(s) |
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