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High-Relaxivity Gd(III)–Hemicryptophane Complex

Abstract : The polytopic hemicryptophane cage HC1 combining a cyclotriveratrylene (CTV) unit and a tris(2- aminoethyl)amine (tren) moiety connected by three 2- hydroxyisophthalamide linkers was synthesized in 12 steps. The resulting highly functionalized covalent host is soluble in aqueous medium and has been used to complex Gd(III) ion. The Gd(III)@HC1 complex presents promising relaxivity properties when compared to the clinically used Dotarem MRI agent.
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https://hal.univ-lorraine.fr/hal-02092702
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Submitted on : Monday, March 23, 2020 - 11:25:34 AM
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Estelle Godart, Augustin Long, Roselyne Rosas, Gilles Lemercier, Marion Jean, et al.. High-Relaxivity Gd(III)–Hemicryptophane Complex. Organic Letters, American Chemical Society, 2019, 21 (7), pp.1999-2003. ⟨10.1021/acs.orglett.9b00081⟩. ⟨hal-02092702⟩

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