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Journal Articles Bio-Medical Materials and Engineering Year : 2008

A novel bioreactor of ligament and tendon for Tissue Engineering


Bioreactors are defined as devices in which biological and/or biochemical processes develop under closely monitored and tightly controlled environmental and operating conditions (e.g. pH, temperature, mechanical conditions, nutrient supply and waste removal). In functional tissue engineering of musculoskeletal tissues, a bioreactor capable of controlling dynamic loading plays a determinant role. It has been shown that mechanical stretching promotes the expression of type I and III collagens, fibronectin, tenascin-C in cultured ligament fibroblasts (J.C.-H. Goh et al., Tissue Eng. 9 (2003), S31) and that human bone marrow mesenchymal stem cells (hBMMSC) – even in the absence of biochemical regulators – could be induced to differentiate into ligament-like fibroblast by the application of physiologically relevant cyclic strains (G. Vunjak-Novakovic et al., Ann. Rev. Biomed. Eng. 6 (2004), 131; H.A. Awad et al., Tissue Eng. 5 (1999), 267; R.G. Young et al., J. Orthop. Res. 16 (1998), 406). Different bioreactors are commercially available but they are too generic to be used for a given tissue, each tissue showing specific mechanical loading properties. In the case of ligament tissue engineering, the design of a bioreactor is still an open question. Our group proposes a bioreactor allowing cyclic traction–torsion on a scaffold seeded with stem cells.
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hal-02194580 , version 1 (25-07-2019)



Cyril J.F. Kahn, Cédryck Vaquette, Rachid Rahouadj, Xiong Wang. A novel bioreactor of ligament and tendon for Tissue Engineering. Bio-Medical Materials and Engineering, 2008, 18 (4-5), pp.283-287. ⟨10.3233/BME-2008-0538⟩. ⟨hal-02194580⟩
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