Redox modulation of NF-kappaB nuclear translocation and DNA binding in metastatic melanoma. The role of endogenous and gamma-glutamyl transferase-dependent oxidative stress. - Université de Lorraine Accéder directement au contenu
Article Dans Une Revue Tumori Année : 2003

Redox modulation of NF-kappaB nuclear translocation and DNA binding in metastatic melanoma. The role of endogenous and gamma-glutamyl transferase-dependent oxidative stress.

Résumé

The transcription factor NF-kappaB is implicated in the expression of genes involved in cell proliferation, apoptosis and metastasis. In melanoma, high constitutive levels of NF-kappaB activation are usually observed. NF-kappaB is regulated by oxidation/reduction (redox) processes, and the occurrence of constitutive oxidative stress in melanoma cells has been documented. Recent studies of our laboratories showed that the membrane-bound gamma-glutamyl transferase (GGT) enzyme activity--expressed by a number of malignancies, including melanoma--can act as a basal source of superoxide, hydrogen peroxide and other prooxidants.

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Cancer
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Dates et versions

hal-02270675 , version 1 (26-08-2019)

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Silvia Dominici, Athanase Visvikis, Lisa Pieri, Aldo Paolicchi, Marta Valentini, et al.. Redox modulation of NF-kappaB nuclear translocation and DNA binding in metastatic melanoma. The role of endogenous and gamma-glutamyl transferase-dependent oxidative stress.. Tumori, 2003, 89 (4), pp.426-33. ⟨10.1177/03008916030890041⟩. ⟨hal-02270675⟩

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