Redox modulation of NF-kappaB nuclear translocation and DNA binding in metastatic melanoma. The role of endogenous and gamma-glutamyl transferase-dependent oxidative stress.

Abstract : The transcription factor NF-kappaB is implicated in the expression of genes involved in cell proliferation, apoptosis and metastasis. In melanoma, high constitutive levels of NF-kappaB activation are usually observed. NF-kappaB is regulated by oxidation/reduction (redox) processes, and the occurrence of constitutive oxidative stress in melanoma cells has been documented. Recent studies of our laboratories showed that the membrane-bound gamma-glutamyl transferase (GGT) enzyme activity--expressed by a number of malignancies, including melanoma--can act as a basal source of superoxide, hydrogen peroxide and other prooxidants.
Document type :
Journal articles
Complete list of metadatas

https://hal.univ-lorraine.fr/hal-02270675
Contributor : Athanase Visvikis <>
Submitted on : Monday, August 26, 2019 - 10:52:06 AM
Last modification on : Saturday, September 7, 2019 - 1:11:31 AM

Identifiers

  • HAL Id : hal-02270675, version 1
  • PUBMED : 14606649

Collections

Citation

Silvia Dominici, Athanase Visvikis, Lisa Pieri, Aldo Paolicchi, Marta Valentini, et al.. Redox modulation of NF-kappaB nuclear translocation and DNA binding in metastatic melanoma. The role of endogenous and gamma-glutamyl transferase-dependent oxidative stress.. Tumori, Casa Editrice Ambrosiana, 2003, 89 (4), pp.426-33. ⟨hal-02270675⟩

Share

Metrics

Record views

8