Transfert de gènes d’antibiorésistance chez Streptococcus suis par des éléments génétiques mobiles

Abstract : Horizontal gene transfer plays a key role in bacterial evolution. Integrative conjugative elements (ICEs) and integrative mobilizable elements (IMEs) which can transfer by conjugation, carry genes that can provide selective/evolutive advantages, such as pathogenicity and drug resistance, to their hosts. In this study, the involvement of ICEs and IMEs in drug resistance dissemination in S. suis was investigated. This bacterium is a swine and human pathogen with a high rate of drug resistance. An experimental study allowed us to show the conjugative transfer of the tetracycline resistance determinant tet(O) carried by an IME, itself carried by an ICE, between S. suis and S. thermophilus. In silico analysis performed on 18 new genomes of S. suis showed the abundance of MGE and drug resistance genes and their association.
Document type :
Master thesis
File URL :
http://docnum.univ-lorraine.fr/ulprive/BUS_M_2017_NOMBRE_YVES_BIENVENUE.pdf
Complete list of metadatas

https://hal.univ-lorraine.fr/hal-02337506
Contributor : Thèses Ul <>
Submitted on : Tuesday, October 29, 2019 - 2:49:17 PM
Last modification on : Wednesday, October 30, 2019 - 1:37:31 AM

Identifiers

  • HAL Id : hal-02337506, version 1

Collections

Citation

Yves Bienvenue Nombre. Transfert de gènes d’antibiorésistance chez Streptococcus suis par des éléments génétiques mobiles. Microbiologie et Parasitologie. 2017. ⟨hal-02337506⟩

Share

Metrics

Record views

2