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Are infection specialists recommending short antibiotic treatment durations? An ESCMID international cross-sectional survey

Abstract : Objectives: To evaluate the current practice and the willingness to shorten the duration of antibiotic therapy among infection specialists. Methods: Infection specialists giving at least weekly advice on antibiotic prescriptions were invited to participate in an online cross-sectional survey between September and December 2016. The questionnaire included 15 clinical vignettes corresponding to common clinical cases with favourable outcomes; part A asked about the antibiotic treatment duration they would usually advise to prescribers and part B asked about the shortest duration they were willing to recommend. Results: We included 866 participants, mostly clinical microbiologists (22.8%, 197/863) or infectious diseases specialists (58.7%, 507/863), members of an antibiotic stewardship team in 73% (624/854) of the cases, coming from 58 countries on all continents. Thirty-six percent of participants (271/749) already advised short durations of antibiotic therapy (compared with the literature) to prescribers for more than half of the vignettes and 47% (312/662) chose shorter durations in part B compared with part A for more than half of the vignettes. Twenty-two percent (192/861) of the participants declared that their regional/national guidelines expressed durations of antibiotic therapy for a specific clinical situation as a fixed duration as opposed to a range and in the multivariable analysis this was associated with respondents advising short durations for more than half of the vignettes (adjusted OR 1.5, P = 0.02). Conclusions: The majority of infection specialists currently do not advise the shortest possible duration of antibiotic therapy to prescribers. Promoting short durations among these experts is urgently needed.
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Submitted on : Tuesday, November 12, 2019 - 4:30:45 PM
Last modification on : Tuesday, December 6, 2022 - 12:42:13 PM

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Gabriel Macheda, Oliver Dyar, Amandine Luc, Bojana Beovic, Guillaume Béraud, et al.. Are infection specialists recommending short antibiotic treatment durations? An ESCMID international cross-sectional survey. Journal of Antimicrobial Chemotherapy, 2018, 73 (4), pp.1084-1090. ⟨10.1093/jac/dkx528⟩. ⟨hal-02360086⟩



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