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Article Dans Une Revue Journal of Antimicrobial Chemotherapy Année : 2018

Are infection specialists recommending short antibiotic treatment durations? An ESCMID international cross-sectional survey

Résumé

Objectives: To evaluate the current practice and the willingness to shorten the duration of antibiotic therapy among infection specialists. Methods: Infection specialists giving at least weekly advice on antibiotic prescriptions were invited to participate in an online cross-sectional survey between September and December 2016. The questionnaire included 15 clinical vignettes corresponding to common clinical cases with favourable outcomes; part A asked about the antibiotic treatment duration they would usually advise to prescribers and part B asked about the shortest duration they were willing to recommend. Results: We included 866 participants, mostly clinical microbiologists (22.8%, 197/863) or infectious diseases specialists (58.7%, 507/863), members of an antibiotic stewardship team in 73% (624/854) of the cases, coming from 58 countries on all continents. Thirty-six percent of participants (271/749) already advised short durations of antibiotic therapy (compared with the literature) to prescribers for more than half of the vignettes and 47% (312/662) chose shorter durations in part B compared with part A for more than half of the vignettes. Twenty-two percent (192/861) of the participants declared that their regional/national guidelines expressed durations of antibiotic therapy for a specific clinical situation as a fixed duration as opposed to a range and in the multivariable analysis this was associated with respondents advising short durations for more than half of the vignettes (adjusted OR 1.5, P = 0.02). Conclusions: The majority of infection specialists currently do not advise the shortest possible duration of antibiotic therapy to prescribers. Promoting short durations among these experts is urgently needed.

Dates et versions

hal-02360086 , version 1 (12-11-2019)

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Gabriel Macheda, Oliver Dyar, Amandine Luc, Bojana Beovic, Guillaume Béraud, et al.. Are infection specialists recommending short antibiotic treatment durations? An ESCMID international cross-sectional survey. Journal of Antimicrobial Chemotherapy, 2018, 73 (4), pp.1084-1090. ⟨10.1093/jac/dkx528⟩. ⟨hal-02360086⟩
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