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Generational changes in multiple sclerosis phenotype in North African immigrants in France: A population-based observational study

Abstract : Background: The incidence of multiple sclerosis (MS) changes from generation to generation in ethnically different immigrants compared with native-born people. We aimed to determine whether there are generational changes in MS phenotypes among North African immigrants in France. Methods: Cohort study with data from a population-based MS registry to compare the clinical characteristics of 80 first (NAG1) and 167 second (NAG2) generation North Africans with MS living in France with 5200 native-born Europeans. Adjusted Cox models were used to test the association between scores of 3 and 6 on the expanded disability status scale (EDSS) and the "origin/generation" variable. Results: Cox models for EDSS scores 3 and 6 showed a higher risk of score 3 (hazard ratio = 1.738, 95% confidence interval 1.237 to 2.444; P = .002) and 6 (hazard ratio = 2.372, 95% confidence interval 1.626 to 3.462; P<.0001) for NAG1 than Europeans. Being NAG2 was not significantly associated with higher hazards of scores 3 and 6. Conclusions: We found two different phenotypes among NAG1 and NAG2 MS patients in France. NAG1, but not NAG2, have a higher risk of disability than Europeans. This raises the question of environmental factors in MS expression, and advocates appropriate patient management according to generation in immigrants.
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https://hal.univ-lorraine.fr/hal-02361080
Contributor : Sylvie Vialaron <>
Submitted on : Wednesday, November 13, 2019 - 11:11:04 AM
Last modification on : Wednesday, March 17, 2021 - 9:00:22 AM

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Clotilde Nardin, Clotilde Latarche, Marc Soudant, Camille Dahan, Maud Michaud, et al.. Generational changes in multiple sclerosis phenotype in North African immigrants in France: A population-based observational study. PLoS ONE, Public Library of Science, 2018, 13 (3), pp.e0194115. ⟨10.1371/journal.pone.0194115⟩. ⟨hal-02361080⟩

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