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Dual function of Lectins - new perspectives in targeted Photodynamic therapy

Abstract : Porphyrins and phthalocyanines are photosensitizers (PS) that are used in clinical imaging, detection of cancer cells and are particularly applied in photodynamic therapy (PDT). Many scientists have been focused on the design of different porphyrin compounds. However, similar to other anti-cancer agents, they cannot recognize selectively tumor tissues. Scientists are seeking new decisions to overcome this problem and to find appropriate targeted delivery strategies. Plant lectins are especially suitable molecules for such targeting as they preferentially recognize specific antigens on the glycosylated cancer cells. This review will give more detailed information about the dual function of lectins and their interactions with PSs, which is a new perspective in targeted PDT. The implications and potential applications of such studies will also be discussed.
Keywords : PDT targeting lectins
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https://hal.univ-lorraine.fr/hal-02382103
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Submitted on : Tuesday, November 17, 2020 - 2:02:50 PM
Last modification on : Wednesday, November 18, 2020 - 3:01:14 AM

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Vanya Bogoeva, Lidiya Petrova, Anna Yordanova, Julie Bouckaert, Ivan Ivanov, et al.. Dual function of Lectins - new perspectives in targeted Photodynamic therapy. Journal of Porphyrins and Phthalocyanines, World Scientific Publishing, 2019, 23 (11), pp.1241 - 1250. ⟨10.1142/S1088424619300209⟩. ⟨hal-02382103⟩

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