GNAI2 variants predict nonsteroidal anti‐inflammatory drug hypersensitivity in a genome‐wide study
Résumé
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the drugs most frequently involved in drug hypersensitivity reactions through mechanisms that may involve genetic predisposition. We performed a fine-mapping GWAS in patients with NSAID-induced hypersen-sitivity reactions with cross-intolerance belonging to the group of NSAID-induced urticaria, angioedema, and anaphylaxis (NIUAA) (2) and matched controls from South Spain, and we replicated the re-sults in patients and paired controls from central Spain. GNAI2 was a significant predictor of NSAID-induced hypersensitivity reactions. This association may reflect its influence on the activation of leukot-riene receptors and the recruitment of immune cells involved in the pathological mechanisms of NSAID hypersensitivity.