Skip to Main content Skip to Navigation
Journal articles

GNAI2 variants predict nonsteroidal anti‐inflammatory drug hypersensitivity in a genome‐wide study

Abstract : Nonsteroidal anti-inflammatory drugs (NSAIDs) are the drugs most frequently involved in drug hypersensitivity reactions through mechanisms that may involve genetic predisposition. We performed a fine-mapping GWAS in patients with NSAID-induced hypersen-sitivity reactions with cross-intolerance belonging to the group of NSAID-induced urticaria, angioedema, and anaphylaxis (NIUAA) (2) and matched controls from South Spain, and we replicated the re-sults in patients and paired controls from central Spain. GNAI2 was a significant predictor of NSAID-induced hypersensitivity reactions. This association may reflect its influence on the activation of leukot-riene receptors and the recruitment of immune cells involved in the pathological mechanisms of NSAID hypersensitivity.
Document type :
Journal articles
Complete list of metadatas

https://hal.univ-lorraine.fr/hal-02504120
Contributor : Philippe de Carvalho <>
Submitted on : Tuesday, March 10, 2020 - 2:43:27 PM
Last modification on : Tuesday, October 13, 2020 - 10:47:29 AM

Identifiers

Citation

Miguel Blanca, Abderrahim Oussalah, José Antonio Cornejo‐garcía, Natalia Blanca‐lópez, Rosa-Maria Guéant-Rodriguez, et al.. GNAI2 variants predict nonsteroidal anti‐inflammatory drug hypersensitivity in a genome‐wide study. Allergy, Wiley, 2019, 8 (2), pp.809-811. ⟨10.1111/all.14100⟩. ⟨hal-02504120⟩

Share

Metrics

Record views

114