National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: a pooled analysis of 458 population-based studies in Asian and Western countries - Université de Lorraine Access content directly
Journal Articles International Journal of Epidemiology Year : 2020

National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: a pooled analysis of 458 population-based studies in Asian and Western countries

Cristina Taddei (1) , Rod Jackson (2) , Bin Zhou (1) , Honor Bixby (1) , Goodarz Danaei (3) , Mariachiara Di Cesare (4) , Kari Kuulasmaa (5) , Kaveh Hajifathalian (6) , James Bentham (7) , James E. Bennett (1) , Wichai Aekplakorn (8) , Renata Cífková (9) , Jean Dallongeville (10) , Dirk Debacquer (11) , Simona Giampaoli (12) , Vilmundur Gudnason (13) , Young-Ho Khang (14) , Tiina Laatikainen (5) , Jim I Mann (15) , Pedro Marques-Vidal (16) , George A Mensah , Martina Müller-Nurasyid (17) , Toshiharu Ninomiya (18) , Janina Petkeviciene , Fernando Rodríguez-Artalejo (19, 20) , Jennifer Servais , Stefan Söderberg (21) , Bill Stavreski , Tom Wilsgaard (22) , Tomasz Zdrojewski (23) , Dong Zhao (24) , Gretchen A Stevens (25) , Stefan Savin (25) , Melanie J Cowan (25) , Leanne M Riley (25) , Majid Ezzati (1) , Robert J Adams (26) , Wolfgang Ahrens (27) , Philippe Amouyel (28) , Antoinette Amuzu (29) , Sigmund A Anderssen (30) , Inger Ariansen (31) , Dominique Arveiler (32) , Thor Aspelund (33) , Juha Auvinen (34) , Mária Avdicová (35) , Maciej Banach (36) , Piotr Bandosz (23) , José R Banegas (19) , Carlo M Barbagallo (37) , Iqbal Bata (38) , Louise A Baur (39) , Robert Beaglehole (2) , Gailute Bernotiene , Yufang Bi , Asako Bienek (40) , Cecilia Björkelund (41) , Simona Bo (42) , Bernhard O Boehm (43) , Marialaura Bonaccio (44) , Vanina Bongard (45) , Rossana Borchini , Herman Borghs , Juergen Breckenkamp (46) , Hermann Brenner (47) , Graziella Bruno (42) , Markus A Busch (48) , Antonio Cabrera de León (49) , Vincenzo Capuano , Felipe F Casanueva (50) , Juan-Pablo Casas (51) , Carmelo A Caserta , Laura Censi , Fangfang Chen , Shuohua Chen , María-Dolores Chirlaque (20) , Belong Cho (14) , Yumi Cho , Jerzy Chudek (52) , Frank Claessens (53) , Janine Clarke , Els Clays (11) , Cyrus Cooper (54) , Simona Costanzo (44) , Dominique Cottel (55) , Chris Cowell (39) , Ana B Crujeiras , Liufu Cui , Graziella d'Arrigo , Luc Dauchet (56) , Guy de Backer (11) , Dirk de Bacquer (11) , Giovanni de Gaetano (44) , Stefaan de Henauw (11) , Delphine de Smedt (11) , Elaine Dennison (54) , Valérie Deschamps (57) , Augusto Di Castelnuovo , Annette J Dobson (58) , Chiara Donfrancesco (12) , Angela Döring (17) , Wojciech Drygas , Yong Du (48) , Elzbieta Dziankowska-Zaborszczyk (36) , Robert Eggertsen (41) , Ulf Ekelund (30) , Roberto Elosua (59) , Johan G Eriksson (5) , Alun Evans (60) , David Faeh (61) , Francisco J Felix-Redondo , Daniel Fernández-Bergés , Marika Ferrari , Jean Ferrières (62) , Joseph D Finn (63) , Ann-Sofie Forslund (21) , Maria Forsner (21) , Guillermo Frontera , Yuki Fujita (64) , Zbigniew Gaciong (65) , Fabio Galvano (66) , Jingli Gao , Manoli Garcia-De-La-Hera (20) , Sarah P Garnett (39) , Jean-Michel Gaspoz (67) , Magda Gasull (20) , Louise Gates , Francesco Gianfagna (68) , Tiffany K Gill (26) , Jonathan Giovannelli (56) , David Goltzman (69) , Marcela Gonzalez Gross (70) , Frederic Gottrand (71) , Sidsel Graff-Iversen (31) , Dušan Grafnetter (72) , Ronald D Gregor (38) , Tomasz Grodzicki (73) , Giuseppe Grosso (66) , Grabriella Gruden (42) , Dongfeng Gu , Pilar Guallar-Castillón (19) , Elias F Gudmundsson (13) , Idris Guessous (67) , Johanna Gunnlaugsdottir (13) , Felix Gutzwiller (61) , Rebecca Hardy (51) , Jun Hata (18) , Teresa Haugsgjerd (74) , Alison J Hayes (39) , Jiang He (75) , Yuna He (76) , Sauli Herrala (77) , Ilpo Tapani Hihtaniemi (1) , Michael Hobbs (78) , Wilma M Hopman , José María Huerta (20) , Inge Huybrechts (79) , Licia Iacoviello (44) , Anna G Iannone , Nayu Ikeda , Masanori Iwasaki (80) , Konrad Jamrozik (26) , Imre Janszky (81) , Marjo-Riitta Jarvelin (1, 34) , Grazyna Jasienska (73) , Garry Jennings (13) , Seung-Lyeal Jeong , Chao Qiang Jiang , Michel Joffres (82) , Jari J Jokelainen (34) , Jost B Jonas , Jacek Jóźwiak , Eero O Kajantie (5) , Jussi Kauhanen (83) , Ulrich Keil (84) , Sirkka Keinänen-Kiukaanniemi (77) , Mathilde Kersting , Ursula Kiechl-Kohlendorfer (85) , Stefan Kiechl (85) , Jeongseon Kim , Yeon-Yong Kim , Jurate Klumbiene , Michael Knoflach (85) , Stephanie Ko (40) , Elin Kolle (30) , Raija Korpelainen (34) , Seppo Koskinen (5) , Katsuyasu Kouda (64) , Wolfgang Kratzer (86) , Susi Kriemler (61) , Steinar Krokstad (81) , Urho M Kujala (87) , Pawel Kurjata , Tai Hing Lam (88) , Vera Lanska (72) , Georg Lappas (89) , Lars E Laugsand (81) , Jeonghee Lee , Terho Lehtimäki (90, 91) , Yanping Li (3) , Christa L Lilly (92) , Xu Lin (93) , Lars Lind (94) , Lauren Lissner (41) , Jing Liu (24) , Esther Lopez-Garcia (19) , Roberto Lorbeer (95) , José Eugenio Lozano , Dalia Luksiene , Annamari Lundqvist (5) , Robert Lundqvist , Per Lytsy (94) , Guansheng Ma (96) , Suka Machi (97) , Stefania Maggi , Dianna J Magliano (98) , Enzo Manzato (99) , Ellisiv B Mathiesen (22) , Stela Mclachlan (100) , Rachael M Mclean (15) , Scott B Mclean , Aline Meirhaeghe (28) , Christa Meisinger (17) , Patricia Metcalf (2) , Jie Mi , Jody C Miller (15) , Luis A Moreno (101) , Suzanne N Morin (69) , Malgorzata Mossakowska (102) , Maria L Muiesan (103) , Jaakko Mursu (83) , Harunobu Nakamura (104) , Jana Námešná (35) , Matthias Nauck (95) , Eva Maria Navarrete-Muñoz (20) , William A Neal (92) , Ilona Nenko (73) , Teemu J Niiranen (5, 105) , Guang Ning (106) , Marianna Noale , Sawada Norie , Davide Noto (37) , Terence O'Neill (63) , Dermot O'Reilly (60) , Kyungwon Oh , Örn Olafsson (13) , Fred Michel Paccaud , Andrzej Pajak (73) , Luigi Palmieri (12) , Francesco Panza , Winsome R Parnell (15) , Markku Peltonen (5) , Annette Peters (17) , Astrid Petersmann (95) , Iris Pigeot (27) , Lorenza Pilotto , Aleksandra Piwonska , Pedro Plans-Rubió , Miquel Porta , Jacqueline F Price (100) , Jardena J Puder (16) , Soile E Puhakka (34) , Ricardas Radisauskas , Olli Raitakari (105) , Rafel Ramos , Josep Redon , Fernando Rigo , Maríadelcristo Rodriguez-Perez , Dora Romaguera (107) , Kimmo Ronkainen , Annika Rosengren (108) , Joel Roy , Jean-Bernard Ruidavets (109) , Marcin Rutkowski , Benoît Salanave (110) , Diego Salmeron (111) , Veikko Salomaa (112) , Jukkat Salonen , Massimo Salvetti , Susana Sans , Joukol Saramies , Kai-Uwe Saum , Christa Scheidt-Nave , Anja Schienkiewitz , Sabine Schipf , Carsteno Schmidt , Ben Schöttker (47) , Sylvain Sebert , Abhijit Sen (113) , Jonathane Shaw , Kenji Shibuya , Dong Wookshin , Rahman Shiri , Judith Simons , Leona Simons , Michael Sjöström (114) , Jolanta Slowikowska-Hilczer (115) , Przemyslaw Slusarczyk , Vincenzo Solfrizzi (116) , Emily Sonestedt (117) , Aïcha Soumaré (118) , Jana Staessen , Mariag Stathopoulou , Jostein Steene-Johannessen , Peter Stehle (119) , Jutta Stieber , Doris Stöckl , Jakub Stokwiszewski , Johan Sundström (120) , Paibul Suriyawongpaisal , Abdonas Tamosiunas , Eng Jootan , Anne Taylor , Grethe Tell , Lutgarde Thijs (121) , Hannak Tolonen , Roman Topór-Madry , María Josétormo , Maties Torrent , Shoichiro Tsugane (122) , Tomi-Pekka Tuomainen (123) , Jaakko Tuomilehto (124) , Christophe Tzourio (125) , Hannu Uusitalo (126) , Koen Vanherck , Dirk Vanderschueren (127) , Diego Vanuzzo , Lars Vatten (128) , Tomas Vega , Giovanni Veronesi , Jesús Vioque (129) , Jyrkik Virtanen , Sophie Visvikis-Siest (130) , Peter Vollenweider (131) , Sari Voutilainen (132) , Martine Vrijheid (133) , Aline Wagner (134) , Anne Wagner (5) , Ming-Dong Wang , Qian Wang (135) , Ya Xingwang , S Goya Wannamethee , Wenbin Wei , Peterh Whincup , Andrzej Wiecek (136) , Johann Willeit , Peter Willeit (137) , Bogdan Wojtyniak (138) , Andrew Wong , Mark Woodward (139) , Aleksander Giwercmanwu , Frederickc Wu , Shouling Wu , Haiquan Xu , Liang Xu (140) , Weili Yan , Xiaoguang Yang , Xingwang Ye , Akihiro Yoshihara , Sabina Zambon , Wenhua Zhao (76)
1 Imperial College London
2 University of Auckland [Auckland]
3 Harvard T.H. Chan School of Public Health
4 Middlesex University
5 National Institute for Health and Welfare [Helsinki]
6 Weill Medical College of Cornell University [New York]
7 University of Kent [Canterbury]
8 Mahidol University [Bangkok]
9 UK - Univerzita Karlova [Praha, Česká republika] = Charles University [Prague, Czech Republic]
10 Epidémiologie des maladies chroniques : impact des interactions gène environnement sur la santé des populations
11 UGENT - Universiteit Gent = Ghent University
12 ISS - Istituto Superiore di Sanità = National Institute of Health
13 IHA - Icelandic Heart Association [Kopavogur, Iceland]
14 SNU - Seoul National University [Seoul]
15 University of Otago [Dunedin, Nouvelle-Zélande]
16 CHUV - Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne]
17 Helmholtz Zentrum München = German Research Center for Environmental Health
18 Kyushu University
19 UAM - Universidad Autónoma de Madrid
20 CIBERESP - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health
21 Umeå University
22 UiT - The Arctic University of Norway [Tromsø, Norway]
23 Medical University of Gdańsk
24 CUMS - Capital University of Medical Sciences [Beijing]
25 OMS / WHO - Organisation Mondiale de la Santé / World Health Organization Office
26 University of Adelaide
27 Leibniz Institute for Prevention Research and Epidemiology - BIPS
28 RID-AGE - Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167
29 LSHTM - London School of Hygiene and Tropical Medicine
30 NIH - Norwegian School of Sport Sciences = Norges idrettshøgskole [Oslo]
31 NIPH - Norwegian Institute of Public Health [Oslo]
32 UNISTRA - Université de Strasbourg
33 University of Iceland [Reykjavik]
34 University of Oulu
35 RAPH - Regional Authority of Public Health [Slovaquia]
36 MUL - Medical University of Łódź
37 Università degli studi di Palermo - University of Palermo
38 Dalhousie University [Halifax]
39 The University of Sydney
40 Public Health Agency of Canada
41 GU - Göteborgs Universitet = University of Gothenburg
42 UNITO - Università degli studi di Torino = University of Turin
43 Nanyang Technological University [Singapour]
44 NEUROMED I.R.C.C.S. - Istituto Neurologico Mediterraneo
45 Faculté de Médecine [Rangueil]
46 Universität Bielefeld = Bielefeld University
47 DKFZ - German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg]
48 RKI - Robert Koch Institute [Berlin]
49 ULL - Universidad de La Laguna [Tenerife - SP]
50 USC - Universidade de Santiago de Compostela [Spain]
51 UCL - University College of London [London]
52 University of Silesia in Katowice
53 KU Leuven - Catholic University of Leuven = Katholieke Universiteit Leuven
54 University of Southampton
55 Biomolécules et inflammation pulmonaire
56 Service d'Epidémiologie et de Santé Publique [Lille]
57 Santé publique France - French National Public Health Agency [Saint-Maurice, France]
58 UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations] - The University of Queensland
59 IMIM-Hospital del Mar
60 QUB - Queen's University [Belfast]
61 UZH - Universität Zürich [Zürich] = University of Zurich
62 LEASP - Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps
63 University of Manchester [Manchester]
64 Kindai University
65 Medical University of Warsaw - Poland
66 Unict - Università degli studi di Catania = University of Catania
67 HUG - Geneva University Hospital
68 Uninsubria - Universitá degli Studi dell’Insubria = University of Insubria [Varese]
69 McGill University = Université McGill [Montréal, Canada]
70 UPM - Universidad Politécnica de Madrid
71 LIRIC - Lille Inflammation Research International Center - U 995
72 IKEM - Institute for Clinical and Experimental Medicine
73 UJ - Uniwersytet Jagielloński w Krakowie = Jagiellonian University
74 UiB - University of Bergen
75 Tulane University
76 Chinese Center for Disease Control and Prevention
77 Oulu University Hospital [Oulu]
78 UWA - The University of Western Australia
79 CIRC - IARC - Centre International de Recherche contre le Cancer - International Agency for Research on Cancer
80 Niigata University
81 NTNU - Norwegian University of Science and Technology
82 SFU.ca - Simon Fraser University = Université Simon Fraser
83 University of Eastern Finland
84 WWU - Westfälische Wilhelms-Universität Münster = University of Münster
85 IMU - Innsbruck Medical University = Medizinische Universität Innsbruck
86 Universitätsklinikum Ulm - University Hospital of Ulm
87 JYU - University of Jyväskylä
88 HKU - The University of Hong Kong
89 Sahlgrenska Academy at University of Gothenburg [Göteborg]
90 Tampere University Hospital
91 University of Tampere [Finland]
92 West Virginia University [Morgantown]
93 UCAS - University of Chinese Academy of Sciences [Beijing]
94 Uppsala Universitet [Uppsala]
95 Universität Greifswald - University of Greifswald
96 Peking University [Shenzhen]
97 The Jikei University School of Medicine
98 Baker Heart and Diabetes Institute (AUSTRALIA)
99 Unipd - Università degli Studi di Padova = University of Padua
100 Edin. - University of Edinburgh
101 University of Zaragoza - Universidad de Zaragoza [Zaragoza]
102 IIMCB - International Institute of Molecular and Cell Biology [Warsaw]
103 UniBs - Università degli Studi di Brescia = University of Brescia
104 Konan University [Kobe, Japan]
105 University of Turku
106 Shanghai Jiao Tong University School of Medicine
107 Department of Epidemiology and Biostatistics
108 Department of Emergency and Cardiovascular Medicine, Sahlgrenska Academy
109 Service Epidémiologie clinique et santé publique [CHU Toulouse]
110 USEN - Unité de Surveillance et d'Epidémiologie Nutritionnelle
111 Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain
112 Department of Chronic Disease Prevention
113 Institute for plasma research
114 Department of Biosciences and Nutrition
115 Department of Reproductive Endocrinology
116 UNIBA - Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro
117 Nutritional Epidemiology
118 Neuroépidémiologie
119 Applied Food Science
120 Department of Medical Sciences and Uppsala Clinical Research Center
121 Research Unit Hypertension and Cardiovascular Epidemiology [Louvain, Belgique]
122 National Cancer Center
123 University of Kuopio
124 Epidémiologie cardiovasculaire et métabolique
125 ISPED - Institut de Santé Publique, d'Epidémiologie et de Développement
126 Tampere University
127 Department of Andrology and Endocrinology, Katholieke Universiteit Leuven
128 NTNU - Norwegian University of Science and Technology [Trondheim]
129 Departamento de Salud Pública
130 IGE-PCV - Interactions Gène-Environnement en Physiopathologie Cardio-Vasculaire
131 Department of Internal Medicine
132 School of Public Health and Clinical Nutrition
133 Epidemiologia Ambiental
134 Department of Epidemiology and Public Health, EA 3430
135 LCE - Laboratoire Chrono-environnement (UMR 6249)
136 SUM - Medical University of Silesia
137 Leopold Franzens Universität Innsbruck - University of Innsbruck
138 National Institute of Public Health - National Institute of Hygiene [Poland]
139 The Georges Institute for International Health
140 NRL - Naval Research Laboratory
Bin Zhou
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George A Mensah
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Rossana Borchini
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Herman Borghs
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Vincenzo Capuano
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Carmelo A Caserta
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Laura Censi
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Fangfang Chen
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Shuohua Chen
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Yumi Cho
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Janine Clarke
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Ana B Crujeiras
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Liufu Cui
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Graziella d'Arrigo
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Augusto Di Castelnuovo
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Wojciech Drygas
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Yong Du
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Francisco J Felix-Redondo
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Daniel Fernández-Bergés
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Marika Ferrari
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Maria Forsner
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Guillermo Frontera
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Yuki Fujita
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Jingli Gao
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Louise Gates
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Dongfeng Gu
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Jun Hata
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Jiang He
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Wilma M Hopman
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Anna G Iannone
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Nayu Ikeda
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Imre Janszky
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Seung-Lyeal Jeong
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Chao Qiang Jiang
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Jost B Jonas
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Jacek Jóźwiak
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Mathilde Kersting
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Jeongseon Kim
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Yeon-Yong Kim
  • Function : Author
Jurate Klumbiene
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Pawel Kurjata
  • Function : Author
Jeonghee Lee
  • Function : Author
Lars Lind
José Eugenio Lozano
  • Function : Author
Dalia Luksiene
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Robert Lundqvist
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Stefania Maggi
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Scott B Mclean
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Jie Mi
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Marianna Noale
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Sawada Norie
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Kyungwon Oh
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Fred Michel Paccaud
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Francesco Panza
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Lorenza Pilotto
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Aleksandra Piwonska
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Pedro Plans-Rubió
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Miquel Porta
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Ricardas Radisauskas
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Rafel Ramos
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Josep Redon
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Fernando Rigo
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Dora Romaguera
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Kimmo Ronkainen
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Joel Roy
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Marcin Rutkowski
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Jukkat Salonen
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Massimo Salvetti
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Susana Sans
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Joukol Saramies
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Kai-Uwe Saum
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Christa Scheidt-Nave
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Anja Schienkiewitz
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Sabine Schipf
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Carsteno Schmidt
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Sylvain Sebert
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Jonathane Shaw
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Kenji Shibuya
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Dong Wookshin
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Rahman Shiri
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Judith Simons
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Leona Simons
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Michael Sjöström
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Przemyslaw Slusarczyk
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Emily Sonestedt
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Jana Staessen
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Mariag Stathopoulou
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Jostein Steene-Johannessen
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Jutta Stieber
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Doris Stöckl
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Jakub Stokwiszewski
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Paibul Suriyawongpaisal
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Abdonas Tamosiunas
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Eng Jootan
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Anne Taylor
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Grethe Tell
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Hannak Tolonen
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Roman Topór-Madry
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María Josétormo
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Maties Torrent
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Hannu Uusitalo
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Koen Vanherck
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Diego Vanuzzo
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Tomas Vega
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Giovanni Veronesi
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Jyrkik Virtanen
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Martine Vrijheid
Anne Wagner
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Ming-Dong Wang
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Qian Wang
Ya Xingwang
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S Goya Wannamethee
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Wenbin Wei
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Peterh Whincup
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Johann Willeit
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Andrew Wong
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Aleksander Giwercmanwu
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Frederickc Wu
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Shouling Wu
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Haiquan Xu
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Weili Yan
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Xiaoguang Yang
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Xingwang Ye
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Akihiro Yoshihara
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Sabina Zambon
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Abstract

BACKGROUND: Although high-density lipoprotein (HDL) and non-HDL cholesterol have opposite associations with coronary heart disease, multi-country reports of lipid trends only use total cholesterol (TC). Our aim was to compare trends in total, HDL and non-HDL cholesterol and the total-to-HDL cholesterol ratio in Asian and Western countries. METHODS: We pooled 458 population-based studies with 82.1 million participants in 23 Asian and Western countries. We estimated changes in mean total, HDL and non-HDL cholesterol and mean total-to-HDL cholesterol ratio by country, sex and age group. RESULTS: Since ∼1980, mean TC increased in Asian countries. In Japan and South Korea, the TC rise was due to rising HDL cholesterol, which increased by up to 0.17 mmol/L per decade in Japanese women; in China, it was due to rising non-HDL cholesterol. TC declined in Western countries, except in Polish men. The decline was largest in Finland and Norway, at ∼0.4 mmol/L per decade. The decline in TC in most Western countries was the net effect of an increase in HDL cholesterol and a decline in non-HDL cholesterol, with the HDL cholesterol increase largest in New Zealand and Switzerland. Mean total-to-HDL cholesterol ratio declined in Japan, South Korea and most Western countries, by as much as ∼0.7 per decade in Swiss men (equivalent to ∼26% decline in coronary heart disease risk per decade). The ratio increased in China. CONCLUSIONS: HDL cholesterol has risen and the total-to-HDL cholesterol ratio has declined in many Western countries, Japan and South Korea, with only a weak correlation with changes in TC or non-HDL cholesterol.
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hal-02532973 , version 1 (07-04-2020)

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Cristina Taddei, Rod Jackson, Bin Zhou, Honor Bixby, Goodarz Danaei, et al.. National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: a pooled analysis of 458 population-based studies in Asian and Western countries. International Journal of Epidemiology, 2020, 49 (1), pp.173-192. ⟨10.1093/ije/dyz099⟩. ⟨hal-02532973⟩
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