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Plasma amyloid levels within the Alzheimer's process and correlations with central biomarkers

Olivier Hanon 1, 2 Jean-Sébastien Vidal 1, 2 Sylvain Lehmann 3 Stéphanie Bombois 4 Bernadette Allinquant 5 Jean-Marc Tréluyer 6 Patrick Gelé 7 Christine Delmaire 4 Frédéric Blanc 8 Jean-François Mangin 9, 10 Luc Buee 7 Jacques Touchon 11 Jacques Hugon 12 Bruno Vellas 13 Evelyne Galbrun 14 Athanase Benetos 15 Gilles Berrut 16 Elena Paillaud 17 David Wallon 18 Giovanni Castelnovo 19 Lisette Volpe-Gillot 20 Marc Paccalin 21 Philippe-Henri Robert 22 Olivier Godefroy 23 Thierry Dantoine 24 Vincent Camus 25, 26 Joël Belmin 27 Pierre Vandel 28, 29 Jean-Luc Novella 30, 31 Emmanuelle Duron 1, 2 Anne-Sophie Rigaud 1, 2 Suzanna Schraen-Maschke 7 Audrey Gabelle 11
Abstract : INTRODUCTION:Diagnostic relevance of plasma amyloid β (Aβ) for Alzheimer's disease (AD) process yields conflicting results. The objective of the study was to assess plasma levels of Aβ42 and Aβ40 in amnestic mild cognitive impairment (MCI), nonamnestic MCI, and AD patients and to investigate relationships between peripheral and central biomarkers.METHODS:One thousand forty participants (417 amnestic MCI, 122 nonamnestic MCI, and 501 AD) from the Biomarker of AmyLoïd pepTide and AlZheimer's diseAse Risk multicenter prospective study with cognition, plasma, cerebrospinal fluid (CSF), and magnetic resonance imaging assessments were included.RESULTS:Plasma Aβ1-42 and Aβ1-40 were lower in AD (36.9 [11.7] and 263 [80] pg/mL) than in amnestic MCI (38.2 [11.9] and 269 [68] pg/mL) than in nonamnestic MCI (39.7 [10.5] and 272 [52] pg/mL), respectively (P = .01 for overall difference between groups for Aβ1-42 and P = .04 for Aβ1-40). Globally, plasma Aβ1-42 correlated with age, Mini-Mental State Examination, and APOE ε4 allele. Plasma Aβ1-42 correlated with all CSF biomarkers in MCI but only with CSF Aβ42 in AD.DISCUSSION:Plasma Aβ was associated with cognitive status and CSF biomarkers, suggesting the interest of plasma amyloid biomarkers for diagnosis purpose.Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.
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Olivier Hanon, Jean-Sébastien Vidal, Sylvain Lehmann, Stéphanie Bombois, Bernadette Allinquant, et al.. Plasma amyloid levels within the Alzheimer's process and correlations with central biomarkers. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Wiley, 2018, 14 (7), pp.858-868. ⟨10.1016/j.jalz.2018.01.004⟩. ⟨hal-02533144⟩

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