Skip to Main content Skip to Navigation
Journal articles

Cardiovascular Comorbidities Are the Main Predictors of Cardiac Reverse Remodeling following Kidney Transplantation

Abstract : Background: End-stage renal disease is associated with cardiac remodeling, which is partly reversible after kidney transplantation (KT). We aimed to determine the association of cardiovascular comorbidities or kidney-related factors with cardiac reverse remodeling after KT. Methods: We performed echocardiography in 56 patients (aged 48 ± 15 years, mean ± SD) before and 24 months after undergoing their first KT. Echocardiograms were reviewed using a standardized process with blinding for the patient characteristics and evaluation timing. Multivariable linear regression analysis was used to evaluate the association between comorbidities and changes in cardiac structure and systolic/diastolic function. Results: Left ventricular mass index (LVMI) and diastolic parameters did not change significantly, while left ventricular ejection fraction (LVEF) increased from 63.9 to 69.6% (p = 0.046). Multivariable analysis revealed associations of histories of valvular heart disease with a smaller reduction in LVMI (β = -27.3, p = 0.04), of coronary artery disease or heart failure with a smaller increase in LVEF (β = 7.17, p = 0.02), and of diabetes mellitus with less improvement in E wave (β = -0.19, p = 0.05), e' (β = 4.15, p = 0.046), and E/e' (β = -5.00, p < 0.01). Conclusion: Cardiovascular comorbidities were -associated with less improvement in cardiac structure and function following KT. Our findings suggest that patients with CV comorbidities may experience limited "favorable" reverse cardiac remodeling following KT.
Complete list of metadatas

Cited literature [25 references]  Display  Hide  Download

https://hal.univ-lorraine.fr/hal-02558187
Contributor : Erwan Bozec <>
Submitted on : Wednesday, April 29, 2020 - 12:37:50 PM
Last modification on : Thursday, January 7, 2021 - 4:00:03 PM

Files

KIdneyTransplant_Cardiology202...
Files produced by the author(s)

Identifiers

Collections

Citation

Masatake Kobayashi, Olivier Huttin, Johan Schikowski, Erwan Bozec, Lamiral Zohra, et al.. Cardiovascular Comorbidities Are the Main Predictors of Cardiac Reverse Remodeling following Kidney Transplantation. Cardiology, Karger, 2020, 145 (2), pp.71-76. ⟨10.1159/000504381⟩. ⟨hal-02558187⟩

Share

Metrics

Record views

87

Files downloads

31