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Mechanical Criterion for the Rupture of a Cell Membrane under Compression

Abstract : We investigate the mechanical conditions leading to the rupture of the plasma membrane of an endothelial cell subjected to a local, compressive force. Membrane rupture is induced by tilted microindentation, a technique used to perform mechanical measurements on adherent cells. In this technique, the applied force can be deduced from the measured horizontal displacement of a microindenter’s tip, as imaged with an inverted microscope and without the need for optical sensors to measure the microindenter’s deflection. We show that plasma membrane rupture of endothelial cells occurs at a well-defined value of the applied compressive stress. As a point of reference, we use numerical simulations to estimate the magnitude of the compressive stresses exerted on endothelial cells during the deployment of a stent.
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Contributor : David Gonzalez-Rodriguez Connect in order to contact the contributor
Submitted on : Wednesday, July 15, 2020 - 11:43:23 AM
Last modification on : Thursday, June 3, 2021 - 12:09:41 PM

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David Gonzalez-Rodriguez, Lionel Guillou, François Cornat, Julie Lafaurie-Janvore, Avin Babataheri, et al.. Mechanical Criterion for the Rupture of a Cell Membrane under Compression. Biophysical Journal, Biophysical Society, 2016, 111 (12), pp.2711-2721. ⟨10.1016/j.bpj.2016.11.001⟩. ⟨hal-02899524⟩



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