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Self-assembly of amphiphilic copolymers containing polysaccharide: PISA versus nanoprecipitation, and the temperature effect

Abstract : For many decades, the self-assembly of amphiphilic copolymers containing polysaccharide, called glycopolymers, has been induced in water via nanoprecipitation, whereas the polymerization-induced self-assembly (PISA) approach has been less reported. Using advanced characterization techniques including static/dynamic light scattering and negative-stain/cryo TEM analyses, we studied the impact of the experimental conditions/process on the morphology of formed glyco-nanostructures. A model amphiphilic glycopolymer (Dex-g12-PHPMA400) based on dextran as hydrophilic polysaccharide backbone and poly(2-hydroxypropyl methacrylate) (PHPMA) as hydrophobic grafts was prepared in water using photo-induced RAFT polymerization at 405 nm. On the one hand, our findings revealed that photo-initiated PISA (photo-PISA) at room temperature (RT) led to a mixture of spheres with a significant population of worm-like micelles (WLM), whereas the nanoprecipitation of purified Dex-g12-PHPMA400 led only to spherical micelles. On the other hand, we demonstrate that the morphology of glyco-nanostructures is affected by temperature since performing photo-PISA at 60 °C led to spheres instead of WLM. Finally, our findings revealed that pre-synthesized WLM at RT underwent irreversibly an unusual morphological transition to spheres by heating to 60 °C
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https://hal.univ-lorraine.fr/hal-02945394
Contributor : Jean-Luc Six <>
Submitted on : Tuesday, September 22, 2020 - 11:42:01 AM
Last modification on : Thursday, May 6, 2021 - 10:53:44 AM

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Djallal Ikkene, Ana Andreea Arteni, Malika Ouldali, Jean-Luc Six, Khalid Ferji. Self-assembly of amphiphilic copolymers containing polysaccharide: PISA versus nanoprecipitation, and the temperature effect. Polymer Chemistry, Royal Society of Chemistry - RSC, 2020, 11 (29), pp.4729-4740. ⟨10.1039/d0py00407c⟩. ⟨hal-02945394⟩

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