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Synthesis of dextran-based chain transfer agent for RAFT-mediated polymerization and glyco-nanoobjects formulation

Abstract : Glycopolymers based on dextran are frequently prepared via ATRP, whereas the use of RAFT polymerization is strangely limited due to the difficult synthesis of Dextran-based macromolecular chain transfer agent (DexCTA). The aim of this work is to establish a controlled and reproducible methodology for its preparation. Direct esterification of the hydroxyl dextran functions is the most common method. Our study shows that this latter leads to a very low degree of functionalization. As alternative, we report a reproductible multistep strategy consisting of oxidation, amination, and amidation reactions. Various DexCTAs with tunable degree of substitution (respectively 0.025, 0.045, and 0.06) were successfully prepared. As proof of concept, one of the DexCTAs was involved in the photo-mediated RAFT polymerization of hydroxypropyl methacrylate in DMSO to prepare amphiphilic Dex-g-PHPMA glycopolymers, which can self-assemble in water into monodisperse spherical nano-objects. MTT assays revealed the biocompatibility of all dextran derivatives.
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https://hal.univ-lorraine.fr/hal-02945397
Contributor : Jean-Luc Six <>
Submitted on : Tuesday, September 22, 2020 - 11:43:28 AM
Last modification on : Friday, April 16, 2021 - 5:10:45 PM

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D. Ikkene, A.A. Arteni, H. Song, H. Laroui, J-L. Six, et al.. Synthesis of dextran-based chain transfer agent for RAFT-mediated polymerization and glyco-nanoobjects formulation. Carbohydrate Polymers, Elsevier, 2020, 234, pp.115943. ⟨10.1016/j.carbpol.2020.115943⟩. ⟨hal-02945397⟩

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