Skip to Main content Skip to Navigation
Journal articles

Elicitation of Antimicrobial Active Compounds by Streptomyces-Fungus Co-Cultures

Abstract : The bacteria of the genus Streptomyces and Basidiomycete fungi harbor many biosynthetic gene clusters (BGCs) that are at the origin of many bioactive molecules with medical or industrial interests. Nevertheless, most BGCs do not express in standard lab growth conditions, preventing the full metabolic potential of these organisms from being exploited. Because it generates biotic cues encountered during natural growth conditions, co-culture is a means to elicit such cryptic compounds. In this study, we explored 72 different Streptomyces-fungus interaction zones (SFIZs) generated during the co-culture of eight Streptomyces and nine fungi. Two SFIZs were selected because they showed an elicitation of anti-bacterial activity compared to mono-cultures. The study of these SFIZs showed that co-culture had a strong impact on the metabolic expression of each partner and enabled the expression of specific compounds. These results show that mimicking the biotic interactions present in this ecological niche is a promising avenue of research to explore the metabolic capacities of Streptomyces and fungi.
Complete list of metadata
Contributor : Pierre LEBLOND Connect in order to contact the contributor
Submitted on : Saturday, January 16, 2021 - 11:14:28 AM
Last modification on : Tuesday, August 2, 2022 - 5:53:41 PM


Distributed under a Creative Commons Attribution 4.0 International License

Links full text



Matthieu Nicault, Ali Zaiter, Stéphane Dumarcay, Patrick Chaimbault, Éric Gelhaye, et al.. Elicitation of Antimicrobial Active Compounds by Streptomyces-Fungus Co-Cultures. Microorganisms, MDPI, 2021, 9 (1), pp.178. ⟨10.3390/microorganisms9010178⟩. ⟨hal-03112257⟩



Record views