Calorie Restriction as a New Treatment of Inflammatory Diseases
Résumé
Immoderate calorie intake coupled with a sedentary lifestyle are major determinants of health issues and inflammatory diseases in modern society.
The balance between energy consumption and energy expenditure is critical for longevity. Excessive energy intake and adiposity cause systemic
inflammation, whereas calorie restriction (CR) without malnutrition, exerts a potent anti-inflammatory effect. The objective of this review was to
provide an overview of different strategies used to reduce calorie intake, discuss physiological mechanisms by which CR might lead to improved
health outcomes, and summarize the present knowledge about inflammatory diseases. We discuss emerging data of observational studies and
randomized clinical trials on CR that have been shown to reduce inflammation and improve human health. Adv Nutr 2021;00:1–13.