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Journal Articles Advances in Nutrition Year : 2021

Calorie Restriction as a New Treatment of Inflammatory Diseases

Abstract

Immoderate calorie intake coupled with a sedentary lifestyle are major determinants of health issues and inflammatory diseases in modern society. The balance between energy consumption and energy expenditure is critical for longevity. Excessive energy intake and adiposity cause systemic inflammation, whereas calorie restriction (CR) without malnutrition, exerts a potent anti-inflammatory effect. The objective of this review was to provide an overview of different strategies used to reduce calorie intake, discuss physiological mechanisms by which CR might lead to improved health outcomes, and summarize the present knowledge about inflammatory diseases. We discuss emerging data of observational studies and randomized clinical trials on CR that have been shown to reduce inflammation and improve human health. Adv Nutr 2021;00:1–13.

Dates and versions

hal-03135550 , version 1 (20-08-2021)

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Tunay Kökten, Franck Hansmannel, Ndeye Coumba Ndiaye, Anne-Charlotte Heba, Didier Quilliot, et al.. Calorie Restriction as a New Treatment of Inflammatory Diseases. Advances in Nutrition, 2021, 12 (4), pp.1558-1570. ⟨10.1093/advances/nmaa179⟩. ⟨hal-03135550⟩
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