Skip to Main content Skip to Navigation
Journal articles

Management of Renin-Angiotensin-Aldosterone System blockade in patients admitted to hospital with confirmed coronavirus disease (COVID-19) infection (The McGill RAAS-COVID- 19): A structured summary of a study protocol for a randomized controlled trial

Mona Aflaki 1, 2 Alexandria Flannery 3, 4, 2 João Ferreira 5, 6, 7, 8 Matthew Cheng 9, 2 Nadine Kronfli 2, 9 Ariane Marelli 2, 3 Faiez Zannad 5, 6, 7, 8 James Brophy 2, 3 Jon Afillalo 10 Thao Huynh 2, 3 Nadia Giannetti 2, 3 Amal Bessissow 1, 2 Justin Ezekowitz 11 Renato Lopes 12 Andrew Ambrosy 13, 14 Morgan Craig 15 Abhinav Sharma 2, 3, 4
Abstract : Objectives: The aim of the RAAS-COVID-19 randomized control trial is to evaluate whether an upfront strategy of temporary discontinuation of renin angiotensin aldosterone system (RAAS) inhibition versus continuation of RAAS inhibition among patients admitted with established COVID-19 infection has an impact on short term clinical and biomarker outcomes. We hypothesize that continuation of RAAS inhibition will be superior to temporary discontinuation with regards to the primary endpoint of a global rank sum score. The global rank sum score has been successfully used in previous cardiovascular clinical trials. Trial design: This is an open label parallel two arm (1,1 ratio) randomized control superiority trial of approximately 40 COVID-19 patients who are on chronic RAAS inhibitor therapy.
Complete list of metadata

https://hal.univ-lorraine.fr/hal-03136429
Contributor : Erwan Bozec <>
Submitted on : Tuesday, February 9, 2021 - 4:57:03 PM
Last modification on : Friday, March 5, 2021 - 9:23:37 AM
Long-term archiving on: : Monday, May 10, 2021 - 7:03:48 PM

File

s13063-021-05080-4.pdf
Publisher files allowed on an open archive

Identifiers

Collections

Citation

Mona Aflaki, Alexandria Flannery, João Ferreira, Matthew Cheng, Nadine Kronfli, et al.. Management of Renin-Angiotensin-Aldosterone System blockade in patients admitted to hospital with confirmed coronavirus disease (COVID-19) infection (The McGill RAAS-COVID- 19): A structured summary of a study protocol for a randomized controlled trial. Trials, BioMed Central, 2021, 22 (1), pp.115. ⟨10.1186/s13063-021-05080-4⟩. ⟨hal-03136429⟩

Share

Metrics

Record views

659

Files downloads

158