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Implementation of iMiDEV™, a new fully automated microfluidic platform for radiopharmaceutical production

Abstract : iMiDEV™ microfluidic system is a new automated tool for a small-scale production of radiopharmaceuticals. This new radiochemistry module utilizes microfluidic cassettes capable of producing diversified radiopharmaceuticals in liquid phase reactions in an automated synthesizer. The user interface is intuitive and designed to give the operator all the information required and to allow driving the synthesis either manually or fully automatically. In this work, we have demonstrated liquid phase reaction and presented the first results of an efficient fully automated [18F]NaF radiosynthesis on the iMiDEV™ platform. Different parameters such as a type of cyclotron targets, initial activity, concentration and volume of the fluoride-18 targetry have been investigated in order to elaborate the optimised radiolabelling of the ligand. Single and double sodium [18F]fluoride synthesis procedures have been successfully developed using two chambers of the cassette. A single-dose of radiotracer was produced in an average radiochemical yield of 87% (decay corrected) within 8 min and quality control tests were performed as per European Pharmacopoeia.
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https://hal.univ-lorraine.fr/hal-03215066
Contributor : Charlotte Collet <>
Submitted on : Monday, May 3, 2021 - 10:24:56 AM
Last modification on : Monday, May 10, 2021 - 9:55:40 AM

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Olga Ovdiichuk, Hemantha Mallapura, Florian Pineda, Virginie Hourtané, Bengt Långström, et al.. Implementation of iMiDEV™, a new fully automated microfluidic platform for radiopharmaceutical production. Lab on a Chip, Royal Society of Chemistry, 2021, ⟨10.1039/D1LC00148E⟩. ⟨hal-03215066⟩

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