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COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Sheryl Abdukahil Ali Hssain Younes Tamlihat Kazali Alidjnou Carlos de Brito Jean Assie Diego Rincon Felwa Humaid Hans Bosse Jose Calvache François Carrier Giulio Cavalli Matthew Cheng Hwa Cho Sung Cho Jose Cidade Jose Herreros Barbara Citarella Sebastiano Colombo Arianne Corpuz Charles D’orleans Rafael de Oliveira França Santi Dewayanti Juan Diaz James Douglas Emanuele Mangoni Anne Dyrhol-Riise José Vidal Mohammed Sanharawi Anna Everding Arie Fatoni Eglantine Devouge Letizia Florio Claudio Fonseca Marcela Freire Ana Ribeiro Elena Curto Louis Morlaes Edward Grandin Domenico Grieco Anja Lordemann Antonia Ho Jan Holter Juan Horcajada Carmen Dominguez Ruth Sotomayor Ruth García Darshana Kandamby Simreen Johal Anders Kildal Gry Bekken Malte Vasconcelos Pavan Vecham Eka Lantang Marta Santos Su Lee Gianluigi Bassi Wei Lim Jean Lucet Karl Müller Juan Sanchez Lars Maier Ceila Sant Charbel Eid Celina Martelli Caroline Rego Eva Marwali Juan Jimenez Hugo Maldonado Diego Tutillo Clara Perrot Dimitra Myrodia Pauline Ng Wing Ng Orna Choileain Budha Oinam Ana Oliveira Claudia Orozco-Chamorro Prasan Panda Luis Reyes Ana Rios Maria Nuñez Julia Abreu Aleksander Holten Xavier Choez Hoi Shum Nassima Mohammed Maria Silva Wai Sin Myung Song Maria Uva Magdalena Svistunov Duong Thuy Bharath Vijayaraghavan Rosario Santos-Olmo Huynh Trieu Joy Villanueva Sheryl Ann Abdukahil Ryuzo Abe Laurent Abel 1 Lara Absil Andrew Acker 2 Shingo Adachi Elisabeth Adam Diana Adrião Kate Ainscough Ali Ait Hssain 3 Younes Ait Tamlihat Takako Akimoto Tala Al-Dabbous Abdulrahman Al-Fares Eman Al Qasim Razi Alalqam Beatrice Alex Kévin Alexandre Huda Alfoudri Kazali Enagnon Alidjnou Jeffrey Aliudin Clotilde Allavena Nathalie Allou João Alves Rita Alves Maria Amaral Heidi Ammerlaan Phoebe Ampaw Roberto Andini Claire Andrejak Andrea Angheben François Angoulvant Séverine Ansart Massimo Antonelli Carlos Alexandre Antunes de Brito Yaseen Arabi Irene Aragao Antonio Arcadipane Lukas Arenz Jean-Benoît Arlet Christel Arnold-Day Lovkesh Arora Elise Artaud-Macari Angel Asensio Jean Baptiste Assie Anika Atique Johann Auchabie Hugues Aumaitre Laurène Azemar Cécile Azoulay Benjamin Bach Delphine Bachelet J. Kenneth Baillie Erica Bak Agamemnon Bakakos Firouzé Banisadr Renata Barbalho Wendy Barclay Michaela Barnikel Audrey Barrelet Cleide Barrigoto Romain Basmaci Diego Fernando Bautista Rincon Alexandra Bedossa Sylvie Behilill Aleksandr Beljantsev David Bellemare Anna Beltrame Marine Beluze Nicolas Benech Dehbia Benkerrou Suzanne Bennett Luís Bento Jan-Erik Berdal Delphine Bergeaud Lorenzo Bertolino Simon Bessis Sybille Bevilcaqua Krishna Bhavsar Felwa Bin Humaid François Bissuel Patrick Biston Laurent Bitker Pablo Blanco-Schweizer Mathieu Blot Filomena Boccia Debby Bogaert François Bompart Gareth Booth Diogo Borges Raphaël Borie Jeannet Bos Hans Martin Bosse Elisabeth Botelho-Nevers Lila Bouadma Olivier Bouchaud Sabelline Bouchez Dounia Bouhmani Damien Bouhour Kévin Bouiller Laurence Bouillet Camille Bouisse Anne-Sophie Boureau Maude Bouscambert Jason Bouziotis Bianca Boxma Marielle Boyer-Besseyre Maria Boylan Cynthia Braga Timo Brandenburger Luca Brazzi Dorothy Breen Patrick Breen Kathy Brickell Nicolas Brozzi Nina Buchtele Christian Buesaquillo Polina Bugaeva Marielle Buisson Erlina Burhan Ingrid Bustos Denis Butnaru Sheila Cárcel André Cabie Susana Cabral Eder Caceres Mia Callahan Kate Calligy Jose Andres Calvache João Camões Valentine Campana Paul Campbell Cecilia Canepa Mireia Cantero Pauline Caraux-Paz Filipa Cardoso Filipe Cardoso Sofia Cardoso Simone Carelli Nicolas Carlier Gayle Carney Chloe Carpenter Marie-Christine Carret François Martin Carrier Gail Carson Maire-Laure Casanova Mariana Cascão José Casimiro Bailey Cassandra Silvia Castañeda Nidyanara Castanheira Guylaine Castor-Alexandre Henry Castrillón Ivo Castro Ana Catarino François-Xavier Catherine Roberta Cavalin Giulio Giovanni Cavalli Alexandros Cavayas Adrian Ceccato Minerva Cervantes-Gonzalez Anissa Chair Catherine Chakveatze Adrienne Chan Meera Chand Julie Chas Camille Chassin Anjellica Chen Yih-Sharng Chen Matthew Pellan Cheng Antoine Cheret Thibault Chiarabini Julian Chica Catherine Chirouze Davide Chiumello Hwa Jin Cho Sung Min Cho Bernard Cholley Jose Pedro Cidade Jose Miguel Cisneros Herreros Barbara Wanjiru Citarella Anna Ciullo Jennifer Clarke Sara Clohisey Cassidy Codan Caitriona Cody Alexandra Coelho Gwenhaël Colin Michael Collins Sebastiano Maria Colombo Pamela Combs J. Connelly Marie Connor Anne Conrad Sofía Contreras Graham Cooke Mary Copland Hugues Cordel Amanda Corley Sarah Cormican Sabine Cornelis Arianne Joy Corpuz Grégory Corvaisier Camille Couffignal Sandrine Couffin-Cadiergues Roxane Courtois Charles Crepy D’orleans Sabine Croonen Gloria Crowl Jonathan Crump Claudina Cruz Marc Csete Alberto Cucino Caroline Cullen Matthew Cummings Gerard Curley Elodie Curlier Paula Custodio Frédérick D’aragon Ana da Silva Filipe Charlene da Silveira Eric D’ortenzio Al-Awwab Dabaliz Andrew Dagens Heidi Dalton Jo Dalton Nick Daneman Emmanuelle Dankwa Jorge Dantas Nathalie de Castro Diego de Mendoza Rafael Freitas de Oliveira França Rosanna de Rosa Thushan de Silva Peter de Vries David Dean Marie-Pierre Debray William Dechert Lauren Deconninck Romain Decours Isabelle Delacroix Karen Delavigne Ionna Deligiannis Andrea Dell’amore Pierre Delobel Elisa Demonchy Emmanuelle Denis Dominique Deplanque Pieter Depuydt Mehul Desai Diane Descamps Mathilde Desvallée Santi Rahayu Dewayanti Alpha Diallo Sylvain Diamantis André Dias Juan Jose Diaz Diaz Rodrigo Diaz Kévin Didier Jean-Luc Diehl Wim Dieperink Jérôme Dimet Vincent Dinot Alphonsine Diouf Yael Dishon Félix Djossou Annemarie Docherty Andy Dong Christl Donnelly Maria Donnelly Chloe Donohue Céline Dorival James Joshua Douglas Renee Douma Nathalie Dournon Triona Downer Mark Downing Tom Drake Vincent Dubee François Dubos Alexandra Ducancelle Susanne Dudman Jake Dunning Emanuele Durante Mangoni Silvia Duranti Lucian Durham Bertrand Dussol Xavier Duval Anne Margarita Dyrhol-Riise Carla Eira José Ernesto Vidal Mohammed El Sanharawi Subbarao Elapavaluru Brigitte Elharrar Natalie Elkheir Jacobien Ellerbroek Rachael Ellis Philippine Eloy Tarek Elshazly Isabelle Enderle Ilka Engelmann Vincent Enouf Olivier Epaulard Mariano Esperatti Hélène Esperou Marina Esposito-Farese João Estevão Manuel Etienne Nadia Ettalhaoui Anna Greti Everding Mirjam Evers Isabelle Fabre Amna Faheem Arabella Fahy Cameron Fairfield Pedro Faria Nataly Farshait Arie Zainul Fatoni Karine Faure Mohamed Fayed Niamh Feely Jorge Fernandes Marília Fernandes Susana Fernandes Joana Ferrão Eglantine Ferrand Devouge Mário Ferraz Benigno Ferreira Ricard Ferrer-Roca Claudia Figueiredo-Mello Clara Flateau Tom Fletcher Letizia Lucia Florio Claire Foley Victor Fomin Claudio Duarte Fonseca Tatiana Fonseca Patricia Fontela Simon Forsyth Giuseppe Foti Erwan Fourn Rob Fowler Diego Franch-Llasat Christophe Fraser John Fraser Marcela Vieira Freire Ana Freitas Ribeiro Caren Friedrich Stéphane Fry Nora Fuentes Masahiro Fukuda Joan Gómez-Junyent Valérie Gaborieau Benoît Gachet Rostane Gaci Massimo Gagliardi Jean-Charles Gagnard Amandine Gagneux-Brunon Sérgio Gaião Phil Gallagher Elena Gallego Curto Carrol Gamble Arthur Garan Esteban Garcia-Gallo Rebekha Garcia Denis Garot Valérie Garrait Nathalie Gault Aisling Gavin Alexandre Gaymard Johannes Gebauer Louis Gerbaud Morlaes Nuno Germano Jade Ghosn Marco Giani Carlo Giaquinto Jess Gibson Tristan Gigante Morgane Gilg Guillermo Giordano Michelle Girvan Valérie Gissot Gezy Giwangkancana Daniel Glikman Petr Glybochko Eric Gnall Geraldine Goco François Goehringer Siri Goepel Jean-Christophe Goffard Jonathan Golob Isabelle Gorenne Cécile Goujard Tiphaine Goulenok Margarite Grable Edward Wilson Grandin Pascal Granier Giacomo Grasselli Christopher Green William Greenhalf Segolène Greffe Domenico Luca Grieco Matthew Griffee Fiona Griffiths Ioana Grigoras Albert Groenendijk Anja Grosse Lordemann Heidi Gruner Yusing Gu Jérémie Guedj Dewi Guellec Anne-Marie Guerguerian Daniela Guerreiro Romain Guery Anne Guillaumot Laurent Guilleminault Thomas Guimard Daniel Haber Sheeba Hakak Matthew Hall Sophie Halpin Ansley Hamer Rebecca Hamidfar Terese Hammond Hayley Hardwick Kristen Harley Ewen Harrison Janet Harrison Leanne Hays Jan Heerman Lars Heggelund Ross Hendry Martina Hennessy Aquiles Henriquez-Trujillo Maxime Hentzien Jaime Hernandez-Montfort Astarini Hidayah Dawn Higgins Eibhilin Higgins Samuel Hinton Ana Hipólito-Reis Hiroaki Hiraiwa Julian Hiscox Antonia Ying Wai Ho Alexandre Hoctin Isabelle Hoffmann Oscar Hoiting Rebecca Holt Jan Cato Holter Peter Horby Juan Pablo Horcajada Koji Hoshino Kota Hoshino Catherine Hough Jimmy Ming-Yang Hsu Jean-Sébastien Hulot Samreen Ijaz Hajnal-Gabriela Illes Hugo Inácio Carmen Infante Dominguez Elias Iosifidis Lacey Irvine Sarah Isgett Tiago Isidoro Margaux Isnard Junji Itai Daniel Ivulich Salma Jaafoura Julien Jabot Clare Jackson Nina Jamieson Stéphane Jaureguiberry Jeffrey Javidfar Zabbe Jean-Benoît Florence Jego Synne Jenum Ruth Jimbo Sotomayor Ruth Noemí Jorge García Cédric Joseph Mark Joseph Philippe Jouvet Hanna Jung Ouifiya Kafif Florentia Kaguelidou Sabina Kali Smaragdi Kalomoiri Darshana Hewa Kandamby Chris Kandel Ravi Kant Christiana Kartsonaki Daisuke Kasugai Kevin Katz Simreen Kaur Johal Sean Keating Andrea Kelly Sadie Kelly Lisa Kennedy Kalynn Kennon Younes Kerroumi Evelyne Kestelyn Imrana Khalid Antoine Khalil Coralie Khan Irfan Khan Michelle Kho Saye Khoo Yuri Kida Peter Kiiza Anders Benjamin Kildal Antoine Kimmoun Detlef Kindgen-Milles Nobuya Kitamura Paul Klenerman Gry Kloumann Bekken Stephen Knight Robin Kobbe Malte Kohns Vasconcelos Volkan Korten Caroline Kosgei Karolina Krawczyk Pavan Kumar Vecham Deepali Kumar Ethan Kurtzman Demetrios Kutsogiannis Konstantinos Kyriakoulis Erwan L’her Marie Lachatre Marie Lacoste John Laffey Marie Lagrange Fabrice Laine Marc Lambert François Lamontagne Marie Langelot-Richard Eka Yudha Lantang Marina Lanza Cédric Laouénan Samira Laribi Delphine Lariviere Odile Launay Yoan Lavie-Badie Andrew Law Clément Le Bihan Cyril Le Bris Eve Le Coustumier Georges Le Falher Sylvie Le Gac Quentin Le Hingrat Marion Le Maréchal Soizic Le Mestre Vincent Le Moing Hervé Le Nagard Paul Le Turnier Rafael León Minh Le Marta Leal Santos Ema Leal James Lee Su Hwan Lee Todd Lee Gary Leeming Bénédicte Lefebvre Laurent Lefebvre Benjamin Lefevre François Lellouche Adrien Lemaignen Véronique Lemee Gretchen Lemmink Michela Leone Quentin Lepiller François-Xavier Lescure Olivier Lesens Mathieu Lesouhaitier Claire Levy-Marchal Bruno Levy Yves Levy Gianluigi Li Bassi Janet Liang Wei Shen Lim Bruno Lina Andreas Lind Guillaume Lingas Sylvie Lion-Daolio Keibun Liu Antonio Loforte Navy Lolong Diogo Lopes Dalia Lopez-Colon Paul Loubet Jean Christophe Lucet Carlos Luna Olguta Lungu Liem Luong Dominique Luton Ruth Lyons Fredrik Müller Karl Erik Müller Olavi Maasikas Sarah Macdonald Moïse Machado Gabrielle Macheda Juan Macias Sanchez Jai Madhok Rafael Mahieu Sophie Mahy Lars Siegfrid Maier Mylène Maillet Thomas Maitre Maximilian Malfertheiner Nadia Malik Fernando Maltez Denis Malvy Marina Mambert Victoria Manda Jose Mandei Edmund Manning Aldric Manuel Ceila Maria Sant Ana Malaque Flávio Marino Carolline de Araújo Mariz Charbel Maroun Eid Ana Marques Catherine Marquis Brian Marsh Laura Marsh John Marshall Celina Turchi Martelli Guillaume Martin-Blondel Ignacio Martin-Loeches Alejandro Martin-Quiros Dori-Ann Martin Emily Martin Martin Martinot Caroline Martins Rego Ana Martins João Martins Gennaro Martucci Eva Miranda Marwali Juan Fernado Masa Jimenez David Maslove Sabina Mason Moshe Matan Daniel Mathieu Mathieu Mattei Romans Matulevics Laurence Maulin Natalie Mc Evoy Aine Mccarthy Colin Mccloskey Rachael Mcconnochie Sherry Mcdermott Sarah Mcdonald Samuel Mcelwee Natalie Mcevoy Allison Mcgeer Niki Mcguinness Kenneth Mclean Bairbre Mcnicholas Edel Meaney Cécile Mear-Passard Maggie Mechlin Ferruccio Mele Kusum Menon France Mentré Alexander Mentzer Noémie Mercier Antoine Merckx Blake Mergler Laura Merson António Mesquita Agnès Meybeck Alison Meynert Vanina Meyssonnier Amina Meziane Medhi Mezidi Céline Michelanglei Vladislav Mihnovitš Hugo Miranda Maldonado Mary Mone Asma Moin David Molina Elena Molinos Agostinho Monteiro Claudia Montes Giorgia Montrucchio Sarah Moore Shona Moore Lina Morales-Cely Lucia Moro Diego Rolando Morocho Tutillo Ana Motos Hugo Mouquet Clara Mouton Perrot Julien Moyet Jimmy Mullaert Daniel Munblit Derek Murphy Marlène Murris Dimitra Melia Myrodia Yohan N’guyen Nadège Neant Holger Neb Nikita Nekliudov Raul Neto Emily Neumann Bernardo Neves Pauline Yeung Ng Wing Yiu Ng Orna Ni Choileain Alistair Nichol Stephanie Nonas Marion Noret Lisa Norman Alessandra Notari Mahdad Noursadeghi Karolina Nowicka Saad Nseir Jose Nunez Elsa Nyamankolly Max O’donnell Katie O’hearn Conar O’neil Giovanna Occhipinti Tawnya Ogston Takayuki Ogura Tak-Hyuk Oh Shinichiro Ohshimo Budha Charan Singh Oinam Ana Pinho Oliveira João Oliveira Piero Olliaro David Ong Wilna Oosthuyzen Peter Openshaw Claudia Milena Orozco-Chamorro Andrés Orquera Javier Osatnik Nadia Ouamara Rachida Ouissa Clark Owyang Eric Oziol Diana Póvoas Maïder Pagadoy Justine Pages Mario Palacios Massimo Palmarini Giovanna Panarello Prasan Kumar Panda Mauro Panigada Nathalie Pansu Aurélie Papadopoulos Briseida Parra Jérémie Pasquier Fabian Patauner Luís Patrão Christelle Paul Mical Paul Jorge Paulos William Paxton Jean-François Payen India Pearse Giles Peek Florent Peelman Nathan Peiffer-Smadja Vincent Peigne Mare Pejkovska Ithan Peltan Rui Pereira Daniel Perez Thomas Perpoint Antonio Pesenti Lenka Petroušová Ventzislava Petrov-Sanchez Gilles Peytavin Scott Pharand Michael Piagnerelli Walter Picard Olivier Picone Marie Piel-Julian Carola Pierobon Carlos Pimentel Lionel Piroth Riinu Pius Simone Piva Laurent Plantier Daniel Plotkin Julien Poissy Maria Pokorska-Spiewak Sergio Poli Georgios Pollakis Jolanta Popielska Douwe Postma Pedro Povoa Jeff Powis Sofia Prapa Christian Prebensen Jean-Charles Preiser Vincent Prestre Nicholas Price Anton Prinssen Mark Pritchard Lúcia Proença Oriane Puéchal Gregory Purcell Luisa Quesada Else Quist-Paulsen Mohammed Quraishi Indrek Rätsep Bernhard Rössler Christian Rabaud Marie Rafiq Gabrielle Ragazzo Fernando Rainieri Nagarajan Ramakrishnan Kollengode Ramanathan Blandine Rammaert Christophe Rapp Menaldi Rasmin Cornelius Rau Stanislas Rebaudet Sarah Redl Brenda Reeve Liadain Reid Renato Reis Jonathan Remppis Martine Remy Hanna Renk Liliana Resende Anne-Sophie Resseguier Matthieu Revest Oleksa Rewa Luis Felipe Reyes David Richardson Denise Richardson Laurent Richier Jordi Riera Ana Lúcia Rios Asgar Rishu Patrick Rispal Karine Risso Maria Angelica Rivera Nuñez Nicholas Rizer André Roberto Stephanie Roberts David Robertson Olivier Robineau Ferran Roche-Campo Paola Rodari Simão Rodeia Julia Rodriguez Abreu Emmanuel Roilides Amanda Rojek Juliette Romaru Roberto Roncon-Albuquerque Mélanie Roriz Manuel Rosa-Calatrava Michael Rose Dorothea Rosenberger Andrea Rossanese Bénédicte Rossignol 4, 5 Patrick Rossignol 6, 7, 4, 5 Carine Roy Benoît Roze Clark Russell Steffi Ryckaert Aleksander Rygh Holten Xavier Sánchez Choez Isabela Saba Musharaf Sadat Nadia Saidani Leonardo Salazar Gabriele Sales Stéphane Sallaberry Hélène Salvator Angel Sanchez-Miralles Olivier Sanchez Vanessa Sancho-Shimizu Gyan Sandhu Oana Sandulescu Marlene Santos Shirley Sarfo-Mensah Benjamine Sarton Egle Saviciute Parthena Savvidou Joshua Scarsbrook Tjard Schermer Arnaud Scherpereel Marion Schneider Stephan Schroll Michael Schwameis James Scott-Brown Janet Scott Nicholas Sedillot Tamara Seitz Caroline Semaille Malcolm Semple Eric Senneville Filipa Sequeira Tânia Sequeira Ellen Shadowitz Mohammad Shamsah Pratima Sharma Catherine Shaw Victoria Shaw Nisreen Shiban Nobuaki Shime Hiroaki Shimizu Keiki Shimizu Sally Shrapnel Hoi Ping Shum Nassima Si Mohammed Louise Sigfrid Catarina Silva Maria Joao Silva Wai Ching Sin Vegard Skogen Sue Smith Benjamin Smood Michelle Smyth Morgane Snacken Dominic So Monserrat Solis Joshua Solomon Tom Solomon Emily Somers Agnès Sommet Myung Jin Song Rima Song Tae Song Michael Sonntagbauer Edouard Soum Maria Sousa Uva Marta Sousa Vicente Souza-Dantas Alexandra Sperry Shiranee Sriskandan Thomas Staudinger Stephanie-Susanne Stecher Ymkje Stienstra Birgitte Stiksrud Adrian Streinu-Cercel Anca Streinu-Cercel Samantha Strudwick Ami Stuart David Stuart Asfia Sultana Charlotte Summers Magdalena Surovcová Andrey A. Svistunov Konstantinos Syrigos Jaques Sztajnbok Konstanty Szuldrzynski François Téoulé Shirin Tabrizi Lysa Tagherset Ewa Talarek Sara Taleb Jelmer Talsma Tan Le Van Hiroyuki Tanaka Taku Tanaka Hayato Taniguchi Coralie Tardivon Pierre Tattevin M. Azhari Taufik Richard Tedder João Teixeira Marie-Capucine Tellier Pleun Terpstra Olivier Terrier Nicolas Terzi Hubert Tessier-Grenier Vincent Thibault Simon-Djamel Thiberville Benoît Thill A. Thompson Shaun Thompson David Thomson Emma Thomson Duong Bich Thuy Ryan Thwaites Peter Timashev Jean-François Timsit Bharath Kumar Tirupakuzhi Vijayaraghavan Maria Toki Kristian Tonby Rosario Maria Torres Santos-Olmo Antoni Torres Margarida Torres Théo Trioux Huynh Trung Trieu Cécile Tromeur Ioannis Trontzas Jonathan Troost Tiffany Trouillon Christelle Tual Sarah Tubiana Helen Tuite Lance Turtle Pawel Twardowski Makoto Uchiyama Roman Ullrich Alberto Uribe Asad Usman Luís Val-Flores Stijn van de Velde Marcel van den Berge Machteld van der Feltz Nicky van der Vekens Peter van der Voort Sylvie van der Werf Marlice van Dyk Laura van Gulik Jarne van Hattem Steven van Lelyveld Carolien van Netten Noémie Vanel Henk Vanoverschelde Charline Vauchy Aurélie Veislinger Jorge Velazco Sara Ventura Annelies Verbon César Vieira Joy Ann Villanueva Judit Villar Pierre-Marc Villeneuve Andrea Villoldo Nguyen van Vinh Chau Benoit Visseaux Hannah Visser Aapeli Vuorinen Fanny Vuotto Chih-Hsien Wang Jia Wei Katharina Weil Sanne Wesselius Murray Wham Bryan Whelan Nicole White Aurélie Wiedemann Keith Wille Evert-Jan Wils Ioannis Xynogalas Jacky Suen Sophie Yacoub Masaki Yamazaki Yazdan Yazdanpanah Cécile Yelnik Stephanie Yerkovich Toshiki Yokoyama Hodane Yonis Paul Young Saptadi Yuliarto Marion Zabbe Kai Zacharowski Maram Zahran Maria Zambon Alberto Zanella Konrad Zawadka Hiba Zayyad Alexander Zoufaly David Zucman