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Journal Articles ESC Heart Failure Year : 2021

Identification of sex‐specific biomarkers predicting new‐onset heart failure

1 MUMC - Maastricht University Medical Centre
2 CARIM - Cardiovascular Research Institute Maastricht
3 CIC-P - Centre d'investigation clinique plurithématique Pierre Drouin [Nancy]
4 DCAC - Défaillance Cardiovasculaire Aiguë et Chronique
5 INI-CRCT - Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy]
6 Cardiovascular & Renal Clinical Trialists - CRCT - French-Clinical Research Infrastructure Network - F-CRIN [Paris]
7 LSHTM - London School of Hygiene and Tropical Medicine
8 TATAA Biocenter AB
9 Casa di Cura Quisisana
10 University of Hull [United Kingdom]
11 Castle Hill Hospital
12 Institute of Cardiovascular and Medical Sciences [Glasgow]
13 CIBERCV, Carlos III Institute of Health
14 IdiSNA - Instituto de Investigacion Sanitaria de Navarra
15 UNAV - Universidad de Navarra [Pamplona]
16 Clínica Universidad de Navarra [Pamplona]
17 Netherlands Heart Institute
18 LUMC - Leiden University Medical Center
19 RID-AGE - Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167
20 Fraunhofer ITEM - Fraunhofer Institute for Toxicology and Experimental Medicine
21 Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School
22 Hôpital Lariboisière-Fernand-Widal [APHP]
23 UPCité - Université Paris Cité
24 MASCOT (UMR_S_942 / U942) - Marqueurs cardiovasculaires en situation de stress
25 UMCG - University Medical Center Groningen [Groningen]
26 Non-Profit Research Institute Alliance for the Promotion of Preventive Medicine
27 KU Leuven - Catholic University of Leuven = Katholieke Universiteit Leuven
28 Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Wellbeing
29 University of Glasgow
30 Royal Brompton and Harefield NHS Foundation Trust
31 NHLI - National Heart and Lung Institute [London]


Aims: Heart failure (HF) is common in both men and women, yet disease pathophysiology, presentation, and progression differ between sexes. Studies addressing whether biomarkers predict new onset HF sex-specifically are scarce. This study therefore aims to test the sex-specificity of 252 protein biomarkers for new-onset HF. Methods and results: A matched case-control design in patients selected from cohorts within the HOMAGE consortium was used. Cases (new-onset HF, n = 562) and controls (n = 780) were matched for cohort (PREDICTOR, HEALTH-ABC, & PROSPER), follow-up time (defined as time from entry to incident HF), and age. Incident HF was defined as first hospitalization for HF. Targeted plasma proteins (n = 252) were measured using Proximity Extension Assay technology from O-link. To look for sex differences for new onset HF, we adjusted for cohort, age, and baseline clinical parameters. At baseline, women had a biomarker profile reflecting activated metabolism and immune responses. However, none of the biomarkers had a significant interaction with sex in predicting new onset HF, but four biomarkers had a trend towards sex-specificity (P < 0.013). E-selectin and interleukin 1 receptor antagonist were more female-specific, whereas IL17A and CHIT1 tended to be male sex-specific for incident HF. Conclusions: The majority of biomarkers associated with incident HF did not significantly differ between women and men, despite clear differences in biomarkers at baseline.
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Dates and versions

hal-03273973 , version 1 (29-06-2021)


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Anne Raafs, Job Verdonschot, João Pedro Ferreira, Ping Wang, Timothy Collier, et al.. Identification of sex‐specific biomarkers predicting new‐onset heart failure. ESC Heart Failure, 2021, ⟨10.1002/ehf2.13476⟩. ⟨hal-03273973⟩
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