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Identification of sex‐specific biomarkers predicting new‐onset heart failure

Anne Raafs 1, 2 Job Verdonschot 1, 2 João Pedro Ferreira 3, 4, 5, 6 Ping Wang 1, 2 Timothy Collier 7 Michiel Henkens 1, 2 Jens Björkman 8 Alessandro Boccanelli 9 Andrew Clark 10, 11 Christian Delles 12 Javier Diez 13, 14, 15, 16 Arantxa González 13, 14, 15 Nicolas Girerd 3, 4, 5, 6 J Wouter Jukema 17, 18 Florence Pinet 5, 6, 19 Patrick Rossignol 3, 4, 5, 6 Thomas Thum 20, 21 Nicolas Vodovar 22, 23, 6, 24 Rudolf de Boer 25 Vanessa van Empel 1, 2 Jan Staessen 26, 27 Mark Hazebroek 1, 2 John Cleland 28, 29, 30, 31 Faiez Zannad 3, 4, 5, 6 Stephane Heymans 1, 2, 17, 27
Abstract : Aims: Heart failure (HF) is common in both men and women, yet disease pathophysiology, presentation, and progression differ between sexes. Studies addressing whether biomarkers predict new onset HF sex-specifically are scarce. This study therefore aims to test the sex-specificity of 252 protein biomarkers for new-onset HF. Methods and results: A matched case-control design in patients selected from cohorts within the HOMAGE consortium was used. Cases (new-onset HF, n = 562) and controls (n = 780) were matched for cohort (PREDICTOR, HEALTH-ABC, & PROSPER), follow-up time (defined as time from entry to incident HF), and age. Incident HF was defined as first hospitalization for HF. Targeted plasma proteins (n = 252) were measured using Proximity Extension Assay technology from O-link. To look for sex differences for new onset HF, we adjusted for cohort, age, and baseline clinical parameters. At baseline, women had a biomarker profile reflecting activated metabolism and immune responses. However, none of the biomarkers had a significant interaction with sex in predicting new onset HF, but four biomarkers had a trend towards sex-specificity (P < 0.013). E-selectin and interleukin 1 receptor antagonist were more female-specific, whereas IL17A and CHIT1 tended to be male sex-specific for incident HF. Conclusions: The majority of biomarkers associated with incident HF did not significantly differ between women and men, despite clear differences in biomarkers at baseline.
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https://hal.univ-lorraine.fr/hal-03273973
Contributor : Erwan Bozec <>
Submitted on : Tuesday, June 29, 2021 - 4:09:12 PM
Last modification on : Sunday, August 22, 2021 - 3:17:01 AM

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Anne Raafs, Job Verdonschot, João Pedro Ferreira, Ping Wang, Timothy Collier, et al.. Identification of sex‐specific biomarkers predicting new‐onset heart failure. ESC Heart Failure, Wiley, 2021, ⟨10.1002/ehf2.13476⟩. ⟨hal-03273973⟩

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