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The genomics of heart failure: design and rationale of the HERMES consortium

R Thomas Lumbers 1 Sonia Shah 2 Honghuang Lin 3 Tomasz Czuba 4 Albert Henry 1 Daniel I Swerdlow 1 Anders Mälarstig 5, 6 Charlotte Andersson 7 Niek Verweij 8 Michael V Holmes 9 Johan Ärnlöv 10, 6 Harry Hemingway 1 Neneh Sallah 1 Peter Almgren 4 Krishna G Aragam 11, 7 Geraldine Asselin 12 Joshua D Backman 13 Mary L Biggs 14 Heather L Bloom 15 Eric Boersma 16 Jeffrey Brandimarto 17 Michael R Brown 18 Hans-Peter Brunner-La Rocca 19 David J Carey 20 Mark D Chaffin 7 Daniel I Chasman 21 Olympe Chazara 22 Xing Chen 5 Xu Chen 6 Jonathan H Chung 13 William Chutkow 23 John G F Cleland 24 James P Cook 25 Simon de Denus 12, 26 Abbas Dehghan 27 Graciela E Delgado 28 Spiros Denaxas 1 Alexander S Doney 29 Marcus Dörr 30 Samuel C Dudley 31 Gunnar Engström 4 Tõnu Esko 7, 11 Ghazaleh Fatemifar 1 Stephan B Felix 30, 32 Chris Finan 1 Ian Ford 24 Francoise Fougerousse 33 René Fouodjio 12 Mohsen Ghanbari 16 Sahar Ghasemi 32, 30 Vilmantas Giedraitis 34 Franco Giulianini 21 John S Gottdiener 35 Stefan Gross 30 Daníel F Guðbjartsson 36, 37 Hongsheng Gui 38 Rebecca Gutmann 39 Christopher M Haggerty 40 Pim van Der Harst 8, 41 Åsa K Hedman 6 Anna Helgadottir 37 Hans Hillege 8 Craig L Hyde 5 Jaison Jacob 23 J Wouter Jukema 42, 43 Frederick Kamanu 7, 21 Isabella Kardys 16 Maryam Kavousi 16 Kay-Tee Khaw 44 Marcus E Kleber 28 Lars Køber 45 Andrea Koekemoer 46 Bill Kraus 47 Karoline Kuchenbaecker 1 Claudia Langenberg 44 Lars Lind 34 Cecilia M Lindgren 7, 9 Barry London 48 Luca A Lotta 44 Ruth C Lovering 1 Jian'An Luan 44 Patrik Magnusson 6 Anubha Mahajan 49 Douglas Mann 50 Kenneth B Margulies 17 Nicholas A Marston 21 Winfried März 28 John J V Mcmurray 24 Olle Melander 4, 51 Giorgio Melloni 7, 21 Ify R Mordi 29 Michael P Morley 17 Andrew D Morris 52 Alanna C Morrison 18 Michael W Nagle 5 Christopher P Nelson 46 Christopher Newton-Cheh 11 Alexander Niessner 53 Teemu Niiranen 54, 55 Christoph Nowak 6 Michelle L O'Donoghue 21 Anjali T Owens 17 Colin N A Palmer 29 Guillaume Paré 56 Markus Perola 55 Louis-Philippe Lemieux Perreault 12 Eliana Portilla-Fernandez 16 Bruce M Psaty 14, 57 Kenneth M Rice 14 Paul M Ridker 21, 58 Simon P R Romaine 46 Carolina Roselli 8, 7 Jerome I Rotter 59 Christian T Ruff 21 Marc S Sabatine 21 Perttu Salo 55 Veikko Salomaa 55 Jessica van Setten 60 Alaa A Shalaby 61 Diane T Smelser 40 Nicholas L Smith 57, 14 Kari Stefansson 37, 36 Steen Stender 62 David J Stott 24 Garðar Sveinbjörnsson 37 Mari-Liis Tammesoo 63 Jean-Claude Tardif 12, 26 Kent D Taylor 59 Maris Teder-Laving 63 Alexander Teumer 32, 30 Guðmundur Thorgeirsson 37, 36 Unnur Thorsteinsdottir 37, 36 Christian Torp-Pedersen 64 Stella Trompet 65 Danny Tuckwell 23 Benoit Tyl 33 Andre G Uitterlinden 16 Felix Vaura 55, 54 Abirami Veluchamy 29 Peter M Visscher 66 Uwe Völker 32, 30 Adriaan A Voors 8 Xiaosong Wang 23 Nicholas J Wareham 44 Peter E Weeke 45 Raul Weiss 67 Harvey D White 68 Kerri L Wiggins 14 Heming Xing 23 Jian Yang 66 Yifan Yang 17 Laura M Yerges-Armstrong 69 Bing Yu 70 Faiez Zannad 71, 72, 73, 74 Faye Zhao 23 Regeneron Genetics Center 13 Jemma B Wilk 5 Hilma Holm 37 Naveed Sattar 24 Steven A Lubitz 7, 11 David E Lanfear 38 Svati Shah 47, 75 Michael E Dunn 76 Quinn S Wells 77 Folkert W Asselbergs 1 Aroon D Hingorani 1 Marie-Pierre Dubé 12 Nilesh J Samani 46 Chim C Lang 29 Thomas P Cappola 17 Patrick T Ellinor 7 Ramachandran S Vasan 4 J Gustav Smith 4 
Abstract : Aims: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome-wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow-up following heart failure diagnosis ranged from 2 to 116 months. Forty-nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34-90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of ≥1.10 for common variants (allele frequency ≥ 0.05) and ≥1.20 for low-frequency variants (allele frequency 0.01-0.05) at P < 5 × 10-8 under an additive genetic model. Conclusions: HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction.
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https://hal.univ-lorraine.fr/hal-03357134
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Submitted on : Tuesday, September 28, 2021 - 4:52:07 PM
Last modification on : Monday, February 21, 2022 - 3:10:03 PM
Long-term archiving on: : Wednesday, December 29, 2021 - 7:01:49 PM

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R Thomas Lumbers, Sonia Shah, Honghuang Lin, Tomasz Czuba, Albert Henry, et al.. The genomics of heart failure: design and rationale of the HERMES consortium. ESC Heart Failure, Wiley, 2021, ⟨10.1002/ehf2.13517⟩. ⟨hal-03357134⟩

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