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Journal Articles ESC Heart Failure Year : 2021

The genomics of heart failure: design and rationale of the HERMES consortium

R Thomas Lumbers (1) , Sonia Shah (2) , Honghuang Lin (3) , Tomasz Czuba (4) , Albert Henry (1) , Daniel I Swerdlow (1) , Anders Mälarstig (5, 6) , Charlotte Andersson (7) , Niek Verweij (8) , Michael V Holmes (9) , Johan Ärnlöv (10, 6) , Harry Hemingway (1) , Neneh Sallah (1) , Peter Almgren (4) , Krishna G Aragam (11, 7) , Geraldine Asselin (12) , Joshua D Backman (13) , Mary L Biggs (14) , Heather L Bloom (15) , Eric Boersma (16) , Jeffrey Brandimarto (17) , Michael R Brown (18) , Hans-Peter Brunner-La Rocca (19) , David J Carey (20) , Mark D Chaffin (7) , Daniel I Chasman (21) , Olympe Chazara (22) , Xing Chen (5) , Xu Chen (6) , Jonathan H Chung (13) , William Chutkow (23) , John G F Cleland (24) , James P Cook (25) , Simon de Denus (12, 26) , Abbas Dehghan (27) , Graciela E Delgado (28) , Spiros Denaxas (1) , Alexander S Doney (29) , Marcus Dörr (30) , Samuel C Dudley (31) , Gunnar Engström (4) , Tõnu Esko (7, 11) , Ghazaleh Fatemifar (1) , Stephan B Felix (30, 32) , Chris Finan (1) , Ian Ford (24) , Francoise Fougerousse (33) , René Fouodjio (12) , Mohsen Ghanbari (16) , Sahar Ghasemi (32, 30) , Vilmantas Giedraitis (34) , Franco Giulianini (21) , John S Gottdiener (35) , Stefan Gross (30) , Daníel F Guðbjartsson (36, 37) , Hongsheng Gui (38) , Rebecca Gutmann (39) , Christopher M Haggerty (40) , Pim van Der Harst (8, 41) , Åsa K Hedman (6) , Anna Helgadottir (37) , Hans Hillege (8) , Craig L Hyde (5) , Jaison Jacob (23) , J Wouter Jukema (42, 43) , Frederick Kamanu (7, 21) , Isabella Kardys (16) , Maryam Kavousi (16) , Kay-Tee Khaw (44) , Marcus E Kleber (28) , Lars Køber (45) , Andrea Koekemoer (46) , Bill Kraus (47) , Karoline Kuchenbaecker (1) , Claudia Langenberg (44) , Lars Lind (34) , Cecilia M Lindgren (7, 9) , Barry London (48) , Luca A Lotta (44) , Ruth C Lovering (1) , Jian'An Luan (44) , Patrik Magnusson (6) , Anubha Mahajan (49) , Douglas Mann (50) , Kenneth B Margulies (17) , Nicholas A Marston (21) , Winfried März (28) , John J V Mcmurray (24) , Olle Melander (4, 51) , Giorgio Melloni (7, 21) , Ify R Mordi (29) , Michael P Morley (17) , Andrew D Morris (52) , Alanna C Morrison (18) , Michael W Nagle (5) , Christopher P Nelson (46) , Christopher Newton-Cheh (11) , Alexander Niessner (53) , Teemu Niiranen (54, 55) , Christoph Nowak (6) , Michelle L O'Donoghue (21) , Anjali T Owens (17) , Colin N A Palmer (29) , Guillaume Paré (56) , Markus Perola (55) , Louis-Philippe Lemieux Perreault (12) , Eliana Portilla-Fernandez (16) , Bruce M Psaty (14, 57) , Kenneth M Rice (14) , Paul M Ridker (21, 58) , Simon P R Romaine (46) , Carolina Roselli (8, 7) , Jerome I Rotter (59) , Christian T Ruff (21) , Marc S Sabatine (21) , Perttu Salo (55) , Veikko Salomaa (55) , Jessica van Setten (60) , Alaa A Shalaby (61) , Diane T Smelser (40) , Nicholas L Smith (57, 14) , Kari Stefansson (37, 36) , Steen Stender (62) , David J Stott (24) , Garðar Sveinbjörnsson (37) , Mari-Liis Tammesoo (63) , Jean-Claude Tardif (12, 26) , Kent D Taylor (59) , Maris Teder-Laving (63) , Alexander Teumer (32, 30) , Guðmundur Thorgeirsson (37, 36) , Unnur Thorsteinsdottir (37, 36) , Christian Torp-Pedersen (64) , Stella Trompet (65) , Danny Tuckwell (23) , Benoit Tyl (33) , Andre G Uitterlinden (16) , Felix Vaura (55, 54) , Abirami Veluchamy (29) , Peter M Visscher (66) , Uwe Völker (32, 30) , Adriaan A Voors (8) , Xiaosong Wang (23) , Nicholas J Wareham (44) , Peter E Weeke (45) , Raul Weiss (67) , Harvey D White (68) , Kerri L Wiggins (14) , Heming Xing (23) , Jian Yang (66) , Yifan Yang (17) , Laura M Yerges-Armstrong (69) , Bing Yu (70) , Faiez Zannad (71, 72, 73, 74) , Faye Zhao (23) , Regeneron Genetics Center (13) , Jemma B Wilk (5) , Hilma Holm (37) , Naveed Sattar (24) , Steven A Lubitz (7, 11) , David E Lanfear (38) , Svati Shah (47, 75) , Michael E Dunn (76) , Quinn S Wells (77) , Folkert W Asselbergs (1) , Aroon D Hingorani (1) , Marie-Pierre Dubé (12) , Nilesh J Samani (46) , Chim C Lang (29) , Thomas P Cappola (17) , Patrick T Ellinor (7) , Ramachandran S Vasan (4) , J Gustav Smith (4)
1 UCL - University College of London [London]
2 UCLH - University College London Hospitals
3 BUSM - Boston University School of Medicine
4 Skane University Hospital [Lund]
5 Pfizer
6 Karolinska Institutet [Stockholm]
7 BROAD INSTITUTE - Broad Institute of MIT and Harvard
8 University of Groningen [Groningen]
9 University of Oxford
10 Dalarna University
11 Massachusetts General Hospital [Boston]
12 Montreal Heart Institute - Institut de Cardiologie de Montréal
13 Regeneron Genetics Center, 777 Old Saw Mill River Road, Tarrytown
14 University of Washington [Seattle]
15 Emory University [Atlanta, GA]
16 Erasmus MC - Erasmus University Medical Center [Rotterdam]
17 University of Pennsylvania
18 UTHealth - The University of Texas Health Science Center at Houston
19 MUMC - Maastricht University Medical Centre
20 Department of Molecular and Functional Genomics, Geisinger, Danville, PA
21 BWH - Brigham & Women’s Hospital [Boston]
22 AstraZeneca
23 NIBR - Novartis Institutes for BioMedical Research
24 University of Glasgow
25 University of Liverpool
26 UdeM - Université de Montréal
27 Imperial College London
28 University of Heidelberg, Medical Faculty
29 University of Dundee
30 Universität Greifswald - University of Greifswald
31 University of Minnesota Medical School
32 DZHK - German Center for Cardiovascular Research
33 IRIS - Institut de Recherches Internationales Servier [Suresnes]
34 Uppsala University
35 University of Maryland School of Medicine
36 University of Iceland [Reykjavik]
37 deCODE genetics [Reykjavik]
38 Henry Ford Hospital
39 Carver College of Medicine, University of Iowa
40 ADMI - Geisinger Autism & Developmental Medicine Institute [Danville, PA, USA]
41 ICIN - Netherlands Heart Institute
42 LUMC - Leiden University Medical Center
43 Netherlands Heart Institute
44 CAM - University of Cambridge [UK]
45 Rigshospitalet [Copenhagen]
46 University of Leicester
47 Duke University [Durham]
48 University of Iowa [Iowa City]
49 Genentech, Inc.
50 Washington University School of Medicine in St. Louis
51 Skane University Hospital [Malmo]
52 University of Edinburgh
53 Medizinische Universität Wien = Medical University of Vienna
54 University of Turku
55 National Institute for Health and Welfare [Helsinki]
56 McMaster University [Hamilton, Ontario]
57 KPWHRI - Kaiser Permanente Washington Health Research Institute [Seattle]
58 HMS - Harvard Medical School [Boston]
59 Harbor UCLA Medical Center [Torrance, Ca.]
60 University Medical Center [Utrecht]
61 UPMC - University of Pittsburgh Medical Center [Pittsburgh, PA, États-Unis]
62 Copenhagen University Hospital
63 University of Tartu
64 AAU - Aalborg University [Denmark]
65 Universiteit Leiden = Leiden University
66 UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations] - The University of Queensland
67 OSU - Ohio State University [Columbus]
68 Auckland City Hospital
69 GlaxoSmithKline
70 University of Texas Health Science Center
71 INI-CRCT - Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy]
72 Cardiovascular & Renal Clinical Trialists - CRCT - French-Clinical Research Infrastructure Network - F-CRIN [Paris]
73 Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy]
74 DCAC - Défaillance Cardiovasculaire Aiguë et Chronique
75 Duke University Medical Center
76 Regeneron Pharmaceuticals [Tarrytown, NY]
77 Vanderbilt University [Nashville]
Albert Henry
Olympe Chazara
  • Function : Author
Xing Chen
  • Function : Author
Ian Ford
  • Function : Author
Craig L Hyde
  • Function : Author
Lars Køber
Lars Lind
Anubha Mahajan
  • Function : Author
Ify R Mordi
  • Function : Author
Michael W Nagle
  • Function : Author
Jessica van Setten
Christian Torp-Pedersen
Jian Yang
Yifan Yang
  • Function : Author
  • PersonId : 776245
  • IdRef : 181481286
Bing Yu
Jemma B Wilk
  • Function : Author
Naveed Sattar
Nilesh J Samani
Chim C Lang
  • Function : Author

Abstract

Aims: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome-wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow-up following heart failure diagnosis ranged from 2 to 116 months. Forty-nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34-90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of ≥1.10 for common variants (allele frequency ≥ 0.05) and ≥1.20 for low-frequency variants (allele frequency 0.01-0.05) at P < 5 × 10-8 under an additive genetic model. Conclusions: HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction.
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Dates and versions

hal-03357134 , version 1 (28-09-2021)

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R Thomas Lumbers, Sonia Shah, Honghuang Lin, Tomasz Czuba, Albert Henry, et al.. The genomics of heart failure: design and rationale of the HERMES consortium. ESC Heart Failure, 2021, ⟨10.1002/ehf2.13517⟩. ⟨hal-03357134⟩
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