Skip to Main content Skip to Navigation
Journal articles

Antagonists of Wnt and BMP signaling promote the formation of vertebrate head muscle

Abstract : Recent studies have postulated that distinct regulatory cascades control myogenic differentiation in the head and the trunk. However, although the tissues and signaling molecules that induce skeletal myogenesis in the trunk have been identified, the source of the signals that trigger skeletal muscle formation in the head remain obscure. Here we show that although myogenesis in the trunk paraxial mesoderm is induced by Wnt signals from the dorsal neural tube, myogenesis in the cranial paraxial mesoderm is blocked by these same signals. In addition, BMP family members that are expressed in both the dorsal neural tube and surface ectoderm are also potent inhibitors of myogenesis in the cranial paraxial mesoderm. We provide evidence suggesting that skeletal myogenesis in the head is induced by the BMP inhibitors, Noggin and Gremlin, and the Wnt inhibitor, Frzb. These molecules are secreted by both cranial neural crest cells and by other tissues surrounding the cranial muscle anlagen. Our findings demonstrate that head muscle formation is locally repressed by Wnt and BMP signals and induced by antagonists of these signaling pathways secreted by adjacent tissues.
Complete list of metadata

https://hal.univ-lorraine.fr/hal-03447262
Contributor : Hervé Kempf Connect in order to contact the contributor
Submitted on : Wednesday, November 24, 2021 - 5:08:37 PM
Last modification on : Thursday, November 25, 2021 - 3:03:44 AM

Links full text

Identifiers

Collections

Citation

Eldad Tzahor, Hervé Kempf, Roy Mootoosamy, Andy Poon, Arhat Abzhanov, et al.. Antagonists of Wnt and BMP signaling promote the formation of vertebrate head muscle. Genes and Development, Cold Spring Harbor Laboratory Press, 2003, 17 (24), pp.3087-3099. ⟨10.1101/gad.1154103⟩. ⟨hal-03447262⟩

Share

Metrics

Record views

8