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Arterial and Cardiac Remodeling Associated With Extra Weight Gain in an Isolated Abdominal Obesity Cohort

Abstract : Introduction: This study aims to assess the changes in cardiovascular remodeling attributable to bodyweight gain in a middle-aged abdominal obesity cohort. A remodeling worsening might explain the increase in cardiovascular risk associated with a dynamic of weight gain. Methods: Seventy-five middle-aged subjects (56 ± 5 years, 38 women) with abdominal obesity and no known cardiovascular disease underwent MRI-based examinations at baseline and at a 6.1 ± 1.2-year follow-up to monitor cardiovascular remodeling and hemodynamic variables, most notably the effective arterial elastance (Ea). Ea is a proxy of the arterial load that must be overcome during left ventricular (LV) ejection, with increased EA resulting in concentric LV remodeling. Results: Sixteen obese subjects had significant weight gain (>7%) during follow-up (WG+), whereas the 59 other individuals did not (WG–). WG+ and WG– exhibited significant differences in the baseline to follow-up evolutions of several hemodynamic parameters, notably diastolic and mean blood pressures (for mean blood pressure, WG+: +9.3 ± 10.9 mmHg vs. WG–: +1.7 ± 11.8 mmHg, p = 0.022), heart rate (WG+: +0.6 ± 9.4 min −1 vs. −8.9 ± 11.5 min −1 , p = 0.003), LV concentric remodeling index (WG: +0.08 ± 0.16 g.mL −1 vs. WG−: −0.02 ± 0.13 g.mL −1 , p = 0.018) and Ea (WG+: +0.20 ± 0.28 mL mmHg −1 vs. WG−: +0.01 ± 0.30 mL mmHg −1 , p = 0.021). The evolution of the LV concentric remodeling index and Ea were also strongly correlated in the overall obese population ( p < 0.001, R 2 = 0.31). Conclusions: A weight gain dynamic is accompanied by increases in arterial load and load-related concentric LV remodeling in an isolated abdominal obesity cohort. This remodeling could have a significant impact on cardiovascular risk.
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Submitted on : Friday, December 3, 2021 - 5:13:24 PM
Last modification on : Thursday, April 28, 2022 - 2:18:02 PM
Long-term archiving on: : Friday, March 4, 2022 - 7:29:45 PM


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Damien Mandry, Nicolas Girerd, Zohra Lamiral, Olivier Huttin, Laura Filippetti, et al.. Arterial and Cardiac Remodeling Associated With Extra Weight Gain in an Isolated Abdominal Obesity Cohort. Frontiers in Cardiovascular Medicine, 2021, 8, pp.771022. ⟨10.3389/fcvm.2021.771022⟩. ⟨hal-03465210⟩



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