Electrochemically controlled cocrystallisation of caffeine:1-hydroxy-2-naphthoic acid
Résumé
Controlled formation of cocrystals is an important objective in drug development. Here, cocrystallisation of caffeine and 1-hydroxy-2-naphthoic acid was investigated at the interface between two immiscible electrolyte solutions under chemical polarisation. In this way, selective cocrystallisation was achieved, as verified by X-ray diffraction and Raman spectroscopy. Positive interfacial potentials favoured the formation of one polymorphic form of caffeine:1-hydroxy-2-naphthoic acid cocrystal. This approach to electrochemically controlled cocrystallisation opens up new possibilities for drug development. The search for innovative crystallisation methods is a subject of constant interest as most drugs appear as crystalline forms whose polymorphs may have different toxicity, hygroscopicity or physical and chemical stability. 1-3 An additional issue encountered in drug development is the low stability in humid environments
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