Electrochemically controlled cocrystallisation of caffeine:1-hydroxy-2-naphthoic acid - Université de Lorraine Accéder directement au contenu
Article Dans Une Revue CrystEngComm Année : 2021

Electrochemically controlled cocrystallisation of caffeine:1-hydroxy-2-naphthoic acid

Résumé

Controlled formation of cocrystals is an important objective in drug development. Here, cocrystallisation of caffeine and 1-hydroxy-2-naphthoic acid was investigated at the interface between two immiscible electrolyte solutions under chemical polarisation. In this way, selective cocrystallisation was achieved, as verified by X-ray diffraction and Raman spectroscopy. Positive interfacial potentials favoured the formation of one polymorphic form of caffeine:1-hydroxy-2-naphthoic acid cocrystal. This approach to electrochemically controlled cocrystallisation opens up new possibilities for drug development. The search for innovative crystallisation methods is a subject of constant interest as most drugs appear as crystalline forms whose polymorphs may have different toxicity, hygroscopicity or physical and chemical stability. 1-3 An additional issue encountered in drug development is the low stability in humid environments
Fichier principal
Vignette du fichier
Manuscript version for HAL.pdf (455.16 Ko) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03475331 , version 1 (10-12-2021)

Identifiants

Citer

Magdalena Kaliszczak, Pierrick Durand, Emmanuel Wenger, Manuel Dossot, Franca Jones, et al.. Electrochemically controlled cocrystallisation of caffeine:1-hydroxy-2-naphthoic acid. CrystEngComm, 2021, ⟨10.1039/d1ce01281a⟩. ⟨hal-03475331⟩
35 Consultations
70 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More