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Journal Articles CrystEngComm Year : 2021

Electrochemically controlled cocrystallisation of caffeine:1-hydroxy-2-naphthoic acid

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Abstract

Controlled formation of cocrystals is an important objective in drug development. Here, cocrystallisation of caffeine and 1-hydroxy-2-naphthoic acid was investigated at the interface between two immiscible electrolyte solutions under chemical polarisation. In this way, selective cocrystallisation was achieved, as verified by X-ray diffraction and Raman spectroscopy. Positive interfacial potentials favoured the formation of one polymorphic form of caffeine:1-hydroxy-2-naphthoic acid cocrystal. This approach to electrochemically controlled cocrystallisation opens up new possibilities for drug development. The search for innovative crystallisation methods is a subject of constant interest as most drugs appear as crystalline forms whose polymorphs may have different toxicity, hygroscopicity or physical and chemical stability. 1-3 An additional issue encountered in drug development is the low stability in humid environments
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Dates and versions

hal-03475331 , version 1 (10-12-2021)

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Magdalena Kaliszczak, Pierrick Durand, Emmanuel Wenger, Manuel Dossot, Franca Jones, et al.. Electrochemically controlled cocrystallisation of caffeine:1-hydroxy-2-naphthoic acid. CrystEngComm, 2021, ⟨10.1039/d1ce01281a⟩. ⟨hal-03475331⟩
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